کد: 6032      تعداد بازدید : 8293

رئیس دانشکده

                

 

دكتر سيد اسمعيل سادات ابراهيمي  

 

 
Associate Professor
 AcademicRank:
 
Pharmacy
School:
 
Medicinal Chemistry
Department:
 
Pharmaceutical Sciences Research Center
Research Center:
 
Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran
Address:
 
 
Tel:
 
 
Fax:
 
sesebrahimi@yahoo.com
sesebrahimi@sina.tums.ac.ir
Email:
 
Education
1) Dr. of Pharmacy degree (Pharm.D) fromTehranUniversity1986.
2) Ph.D., Pharmaceutical Chemistry, fromManchesterUniversity,Schoolof
Pharmaceutical Sciences1996.d
 
Positions Held
Assistant Professor of Medicinal Chemistry, Tehran University 1987-1996.
Associate Professor of Medicinal Chemistry, Tehran University 1996-now.
Member of Research Committee of the Faculty of Pharmacy 2000-2003
Member of the Medicinal Plants Research Network of the Ministry of Health 2001-now
Member of the committee of Medicinal plants of the Ministry of Health 2002-now
Member of the committee of Traditional and complementary medicine of the Ministry of Health 2005-now
Member of the Medicinal Plants Research Center of Tehran University of Medical Sciences 2005-now
 
Experiences
1) Dr. of Pharmacy degree (Pharm.D) from Tehran University 1986
 2)Ph.D., Pharmaceutical Chemistry, from Manchester University, School of
 Pharmaceutical Sciences 1996.
Honors, Distinctions, and Scientific Societies Membership
Member of Research Committee of the Faculty of Pharmacy 2000-2003
Member of the Medicinal Plants Research Network of the Ministry of Health 2001-now
Member of the committee of Medicinal plants of the Ministry of Health 2002-now
Member of the committee of Traditional and complementary medicine of the Ministry of Health 2005-now
Member of the Medicinal Plants Research Center of Tehran University of Medical Sciences 2005-now
 
 
Language Skills 
English, Arabic, Turkish
 
Computer Knowledge
Ordinary computer skills
  
Farsi Publications ation
 
تاثير مهاركنندگي عصاره آبي الكلي موسير(Allium hirtrifoliuml)بر روي رشد
 
ليشمانيا ابنفانتوم در شرايط آزمايشگاهي. (1385) فصلنامه گياهان داروئي، (20) 5، 52-48
 
English Publications
1) Studies of the Interaction of a meta-Hydroxy Analogue of Hoechst 33258 with DNA by Melting Temperature, Footprinting and High-resolution 1H NMR Sperctroscopy. J. Chem. Soc. Chem. Commun. (1992)19, 1398- 1399
2) J. Biomol. Struct. Dynamics (1995) 12, 202
3) Synthesis, DNA-binding, Footprinting and in vitro antitumour activity of a meta-hydroxy analogue of Hoechst 33258. Anti-cancer Drug Design, (1995), 10, 463-479
4) Predictability of Designing Specific Binding Interactions for DNA Minor Groove Ligands from NMR Spectroscopy and Molecular Modelling: A Copper (II) – Activated DNA Cleaver based on Hoechst 33258, Biochemistry, (1995) 34, 16240-16244
5) Unique Binding site for Bis-benzimidazoles on transfer RNA. J.Chem.Soc.Chem.Commun. (1997), 385-386
6) Strong specific, Reversible binding Ligands for Transfer RNA: Comparsion by Fluorescence and NMR Spectroscopies with Distamycin binding for a new Structural Class of Ligands. Nucleosides & Nucleotides (1998) 17(9-11), 1651-1665
7) Synthetic Inhibitors of the processing of pre tranfer RNA by the Ribonuclease P Ribozyme: Enzyme Inhibitors which Act by Binding to substracte , Biochemistry (2001) 40 ( 3 ), 603-608
8) Increased stability and lifetime of the complex formed   between DNA and meta-phenyl-substituted Hoechst Dyes as Studied by Fluorescence titrations and Stopped- flow Kinetics. J. Mol. Biol. (2001) 308, 649-663.
9) Experimental Precedent for the Need to Involve the Primary Hydration layer of DNA in Lead Drug Design. J. Med. Chem. (2001), 44, 2503-2506.
10) Three Tetraoxygenated xanthones from Swetia longifolia, Pharmaceutical Biology (2004), 41(7), 497-499
11) Isolation and characterization of a new alkaloid from Thalictrum minus L. (Ranunculanceae) from Iran.
12) Chemical composition of the Essential oils Satureja atropatana and Satureja mutica Growing wildly in Iran. J. Essential Oil Research, in press.
13) Direct Labelling of octreotide with 99m Tc: Effect of different concentration of reducing agents, and amount of sodium pertechnetate on radiolabelling efficiency, Applied Radiation and Isotopes (2003), 58, 361-364.
14) Synthesis, Labelling, formulation and quality control of 99mTc-Tricine-HYNIC-Tyr3-Octreotide, a peptide radiopharmaceutical for imaging somatostatin receptor positive tumors, Iranian Journal of Nuclear Medicine (2003), 19, 23-28.
15) Labdanes and Isopimaranes from Platycladus orientalis and Their Effects on Erythrocyte Membrane and on Plasmodium falciparum Growth in the Erythrocyte Host Cells, J. Nat. Prod. (2004), 67, 631-637.
16) Hepatoprotective effects of Swertia longifolia Boiss and swerchirin on acetaminophen-induced hepatotoxicity, Toxicology and Applied Pharmacology, (2004), 197(3), 299 (655)
17) Preparation, of formulation and quality control of one step kit 99m Tc-EDDA/KYNIC-octre-otide as peptide radiopharmaceutical for imaging somatostatin receptor positive tumors, The Iranian Journal of Nuclear Medicine, (2004), (22), 21-27
18) The Components of tagetes minuta L. and its biological activities against malaria vector, Anopheles stephensi in Iran, Journal of Medicinal Plants, (2005), 4(16), 43-47
19) Chemical composition of the Essential oils of Satureja atropatana and Satureja mutica Growing Wild in Iran, J. Essent. Oil. Res., (2005), 17, 17-18
20) Composition of the volatile Oils of Satureja specigera C. Koch Boiss. And S. macrantha C.A. Mey. from Iran, flavour and Fragrance Journal, (2005), 20
21) Cytotoxic Terenoids from Satureja macrantha C.A. Mey. DARU, (2005), 13(4), 177-
22) Isolation of two Naphthalene Derivatives from Pterocarya Fraxinifolia leaf and Evaluation of Their Biological activities, Chemistry An indian Journal, (2005), 1(12), 70-783
23) Antioxidant Power of Iranian propolis Extract, Food Chemistry, (2006),
24) Protective Effects of Swertia longifolia Boiss. and its avctive compound, swerchirin, on paracetamol-induced hepatotoxicity in mice, Journal of Pharmacy and Pharmacology, (2006), 58, 277-280
25) Synthesis, development and preclinical comparison of two new peptide based freeze-dried kit formulation 99mTc-EDDA-Tricine-HYNIC-TOC and 99mTc-EDDA-Tricine-HYNIC-TATE for somatostatin receptor positive tumor scintigraphy, DARU, (2006), 14(4), 183-
26) Two new xanthone diglycosides from Swertia longifolia Boiss., Natural Product Research, (2006), 20(13), 1251-1257
27) Inhibit Effect of Allium hirtifolium Boiss. (Persian shallot) hydroalcoholic Extract on Growth of Leishmania infantum in Vitro, Journal of Medicinal Plants, (2006), 5(20), 48-52
28) Confirmation of hydrazone formation in HYNIC-peptide conjugate preparation, and its hydrolysis during labeling with 99mTc, Applied radiation and Isotopes, (2007), 65, 805-808.
 
 29) The components of tagetes minuta L.and its biological activities againstmalaria    
    vector, Anopheles stephensi in Iran. J. of Medicinal Plants. (1384) 4 (16), 43-47.
30) Synthesis, development and Preclinical comparison of two new peptide basedfreeze-dried kit formulation 99m Tc-EDDA-Tricine-HYNIC-TOC and 99mTc-EDDA-Tricine-HYNIC-TATE for somatostatin receptor positive tumorscintigraphy. DARU. (2006) 14(4), 183-189.
 
31) Confirmation of hydrazone formation in HYNIC-peptide conjugate preparation, and its hydrolysis during labeling with 99mTc. Applied Radiation and Isotopes. (2007) 65(7), 805-808.
 
32) Influence of Extraction Methods on The Yield and Chemical Composition ofEssential oil of Platycladus orientalis (L).Franco. Jundishapur Journal of Natural Pharmaceutical Products. (2007) 2, 2-15.
 

 

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