Tehran University of Medical Sciences
Office of Vice-Chancellor for Global Strategies & International Affairs
International Human Capacity Development (IHCD)
Code : 9345-332103      Publish Date : Wednesday, December 4, 2013 Visit : 2414

Intl. Congress form | International Congress Report | International Congress Report For Faculty | 15th international congress of immunology 2013 Millan Italy

15th international congress of immunology 2013 Millan Italy
The Report of 15th international congress of immunology 2013 Millan Italy by Dr.aliakbar amirzargar
Application Code :
306-0213-0062
 
Created Date : Monday, November 04, 2013Update Date : Tuesday, December 03, 2013IP Address :194.225.51.101
Submit Date : Tuesday, December 03, 2013Email : amirzara@tums.ac.ir
Personal Information
Name : aliakbar
Surname : amirzargar
School/Research center : School of Medicine
If you choose other, please name your Research center :  
Possition : Professor
Tel : +21-889-53009
E-mail : amirzara@tums.ac.ir
Information of Congress
Title of the Congress : 15th international congress of immunology 2013 Millan Italy
Title of your Abstract : KIR and their HLA ligand and aGVHD incidence post HSC Tx
country : Italy
From : Thursday, August 22, 2013
To : Tuesday, August 27, 2013
Abstract(Please copy/paste the abstract send to the congress) :

P6.12.03
KIR & their HLA ligand and aGVHD incidence post HSC TX
A. Amirzargar, s. Hosseinian, M. Mahmoudi, M. Ostadali, K. Alimoghadam, A. Masoud; Tehran university

of medical sciences, Tehran, Iran.Introduction:Killer Ig-like receptor (KIR) play an important role in the outcome of HSC Tx and GVHD

incidence .Material and methods:The study population was comprised of 86 donor and recipient siblings transplanted with hematopoietic cells during March 2010 to June 20111. The patient group consisted of: 29 patient with ALL, 27 patients with AML and 30 with Thalassemia.All the patients and donors were examined for KIR and KIR HLA Ligand by multiplex PCR-SSP method using commercial Olerup KIR and HLA ligand genotyping KIT.Results:The results of this study showed that the presence of 2DL2 in donors is related to aGVHD incidence with a Hazard ratio is 4.21 (P.value =0.001.) by contrast, presence of 2DS4 (o.125 Hazard ratio and 0.000 P.value)and 3DS1 (Hazard ratio= o.248 and P.value=0.000) is associated with reduction of aGVHD incidence.Inconclusion:Accordingly donor NK cells can destroy their alloreactive targets. If malignant cells remained after chemotherapy targeted by NK cells and prevent relapsing the disease. The result of this study is in accordance with Ruggeri`s study which found that alloreactivity prevents aGVHD. Therefore,Nk cells alloreactivity by destroying APC prevent recipient antigen from presenting to T cells which are the most important cells in aGVHD and consequently preventing disease occurance .

Keywords of your Abstract : KIR , HLA ligand, HSC TX, aGVHD
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/12058/Forms/306/ici2013 abst acceptance_6.docx
The presentation : Poster
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/12058/Forms/306/cover_1.docx
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/12058/Forms/306/abstract_of_the_ms.docx
Where has your abstract been indexed? : ISI
If you choose other, please name : IUIS
The Congress Reporting Form
How many volunteers were present at the Congress? : about 500
Delegates from which countries presented in the congress? : usa, europ , asia and africa ,as this is an international congress in the Immunology feild and every 3-4 years will be held alot of scientistit from different countries will participate.
Were the delegates of any other organizations present in the congress? : No
If yes, please write the names of the organizations in the box :  
What were the responses to your talking points? Were specific questions or concerns raised? : some of the delegate asking about our work especilly in KIR genotyping in Thalasemia patients and also in ALL and AML patients and the significace of some genotype and their differences in acute leukemia ,
If you met staff members, please list their full names & positions. : no
Please inform us if there are any follow up actions we need to talk with the members of the congress : no , but some of our colleages talking with some of delegate regarding to inviation of them to participate and present their scientific lectures and also if their work are top in the feild ,ask them to present thier work in the plennary lecture setions . the next Immunology congress in Iran will be held in april 2014 in mahmoud abad , mazandaran province in the next year . some of these person possibly professor Zikernagar the Noble prize winner accept the iranian society of Immunology (ISI) to attend in Iran and paticipate in the congress and present his lecture in the pelannary session , but I think an official and finacial support from the university is necessary , and I think the staff of the Iran society for Immunology will follow the invitation and informing the responsible person in the tehran university of medical sciences the research deputy and also the vice chancellor for global strategies and international affairs should helping the ISI staff for arranging the invitation of the sceintitis to IRAN for this congress .
Your experiences about the travel processes(Providing ticket, accommodation,...) : excellent
Please give a briefing of your own observations and outcomes of the congress: : it was intersting for me that our research work in our country is relatively uptodate . our abstract was entitled as KIR and their HLA ligand in aGVHD in cidence post hematopoetic stem cell transplantaion , it is very important as in bone marrow trnasplantation service in Iran Shariaty hospital donor allocation is base on identical siblings regarding HLA typing , however in these patients we have 30 persent aGVHD , so it seems that other genes are also important in the occurance of aGVHD. so our poposal was important to if Killer immunoglobulin like receptor play arole in the aGVHD incidence and most of our poster wiever was in tersteted to know if the KIR genotype and HLA ligands are vluable in donor allocation in bone marrow or sten cell trnasplantation service.