Tehran University of Medical Sciences
Office of Vice-Chancellor for Global Strategies & International Affairs
International Human Capacity Development (IHCD)
Code : 9822-334161      Publish Date : Sunday, February 23, 2014 Visit : 2990

Intl. Congress form | International Congress Report | International Congress Report For Students and Staff | 4th international congress of leukemia lymphoma & myeloma

4th international congress of leukemia lymphoma & myeloma
The Report of 4th international congress of leukemia lymphoma & myeloma by zahra kashanikhatib
Application Code :
306-0114-0018
 
Created Date : Sunday, February 16, 2014 09:43:32Update Date : Saturday, February 22, 2014 15:36:13IP Address : 192.168.105.77
Submit Date : Saturday, February 22, 2014 15:36:44Email : zkashanikhatib@gmail.com
Personal Information
Name : zahra
Surname : kashanikhatib
School/Research center : School of Allied Medical Sciences
If you choose other, please name your Research center :  
Possition : student
Tel : +98-21-8880345
E-mail : zkashanikhatib@gmail.com
Information of Congress
Title of the Congress : 4th international congress of leukemia lymphoma &myeloma
Title of your Abstract : Evaluation of miR-155 inhibition effects on Jurkat cell line
country : Turkey
From : Wednesday, May 22, 2013
To : Saturday, May 25, 2013
Abstract(Please copy/paste the abstract send to the congress) : Abstract:
Objectives: MicroRNAs are small non-coding RNA molecules with approximately 22 nt in length and cause inhibition of translation or degradation of mRNA. Mir-155 is a molecule with different functions, such as role in proliferation and immunity. Overexpression of this miRNA has been found in a number of cancers. One of its best known functions is apoptosis that affectsa on caspase-3 activity. The main aim of this study was evaluation of LNA mir-155 inhibitor effect in apoptosis. Methods: In this study, Jurkat cells were used and for evaluation of sensitivity to varied concentrations (25, 50 and 75 nmol) of mir-155 inhibitor using MTT assay. Mir-155 expression level was analyzed using the quantitative real-time polymerase chain reaction (QRT-PCR). Caspase-3 activity was measured by caspase-3 colorimetric activity assay kit. Unpaired t test test were used for analysis of the MTT and apoptosis results. Probability of 5% was assumed as statistically significant. Results: According to our results, the use of mir-155 inhibitor increased activity of caspase-3 by 2 fold in 75 nmol concentration. In this research, we found that the proper increase of mir-155 inhibitor concentration can inhibit mir-155 and consequently increase caspase-3 activity and induce apoptosis in the Jurkat cells leading to cell death ultimately. Conclusions: Apoptosis stimulation by miRNAs is probably one of the best and low risk ways of cell death induction in malignancies. Due to role of mir-155 in several cancer cells, it may be used as a therapeutic tool in future.
Keywords of your Abstract : miRNA, mir-155 inhibitor, Apoptosis
Acceptance Letter :
The presentation : Poster
The Cover of Abstract book :
Published abstract in the abstract book with the related code :
Where has your abstract been indexed? : ISI
If you choose other, please name :  
The Congress Reporting Form
How many volunteers were present at the Congress? : about 600 person
Delegates from which countries presented in the congress? : USA, England, France, Brasil, Jopan,...
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : EHA, ASh
What were the responses to your talking points? Were specific questions or concerns raised? : familirize with new points in diagnosis and management of blood disease and cancers. new classification and so on.
also I want to survey the structure of international congress from travel to participation .
the other benefit of this congress was the chnce for meeting pioneers of hematology subjests such as leukemia, lymphoma, myeloma, MPN, MDs.
also in this congress was uesful discussion about new approch about classification. diagnosis and managment of blood disease and malignancies.
If you met staff members, please list their full names & positions. : Muzaffer Demir
Trakya University, School of Medicine, Department of Hematology, Edirne, Turkey

İbrahim Haznedaroğlu
Hacettepe University, School of Medicine, Department of Hematology, Ankara, Turkey

H. Joachim Deeg 
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Please inform us if there are any follow up actions we need to talk with the members of the congress : no are any follow up actions we need to talk with the members of the congress, we also sent them a manuscript for evaluation and publication for turkish journal of hematology.
Your experiences about the travel processes(Providing ticket, accommodation,...) : without any problem. only the payment of registeration fee for students is major problem
Please give a briefing of your own observations and outcomes of the congress: : I meet Turkish society of Hematology, hematology journals editors, and famous professors in hematology. Congress workers were also treated properly. All the planning was done in a timely fashion and lecture schedule