Tehran University of Medical Sciences
Office of Vice-Chancellor for Global Strategies & International Affairs
International Human Capacity Development (IHCD)
Code : 9345-336075      Publish Date : Tuesday, April 8, 2014 Visit : 2194

Intl. Congress form | International Congress Report | International Congress Report For Faculty | 2014 AAAAI Annual Meeting

2014 AAAAI Annual Meeting
The Report of 2014 AAAAI Annual Meeting by Dr.Nima Rezaei
Application Code :
306-0114-0025
 
Created Date : Sunday, February 02, 2014 17:52:04Update Date : Monday, March 17, 2014 13:50:04IP Address : 194.225.212.150
Submit Date : Monday, March 17, 2014 13:50:23Email : rezaei_nima@yahoo.com
Personal Information
Name : Nima
Surname : Rezaei
School/Research center : School of Medicine
If you choose other, please name your Research center :  
Possition : Assistant professor
Tel : +21-669-29234
E-mail : rezaei_nima@yahoo.com
Information of Congress
Title of the Congress : 2014 AAAAI Annual Meeting
Title of your Abstract : Interleukin-4 and Transforming Growth Factor-Beta Single Nucleotide Genes Polymorphisms Confer Susceptibility To Atopic Dermatitis
country : USA
From : Friday, February 28, 2014
To : Tuesday, March 04, 2014
Abstract(Please copy/paste the abstract send to the congress) : Rationale: Atopic dermatitis (AD) is a chronic inflammation of the skin, seems to have a strong genetic background. Interleukin-4 (IL-4) is one of the cytokines implicated in promotion of allergic diseases and transforming growth factor-beta (TGF-β) is an anti-inflammatory cytokine promoting counter-regulatory responses to IL-4. This study aimed to investigate association of polymorphisms at genes encoding IL-4 or TGF-β with susceptibility to AD.
Methods: This case-control study comprised 89 children with established diagnosis of AD and 139 healthy controls. Single nucleotide polymorphisms at IL-4 -1098T>G (rs243248), -590C>T (rs2243250), -33C>T (rs2070874), and TGF-β codon10C>T (rs1982073) and codon25G>C (rs1800471) were typed. Frequencies of alleles, genotypes and haplotypes were estimated and compared between patients and controls.
Results: Patients with AD had significantly higher percentage of T allele at IL-4-1098T>G (84.4%) and C allele at IL-4-590C>T(85.0%) and IL-4 -33C>T (84.4%, all p<0.001).TT genotype at IL-4-1098T>G [OR 3.65, 95%CI (1.99-6.71)] and CC genotype at both IL-4-590C>T [OR 31.75, 95%CI (13.61-76.07)] and IL-4-33C>T [OR 3.52, 95%CI (1.92-6.52)] were overrepresented in AD patients (p<0.001). Consistently, TCC haplotype was significantly more frequent in AD patients [(OR 5.15, 95%CI (3.28-8.08), p<0.001]. Considering TGF-β gene in AD patients, C allele was significantly higher at both loci and CC at codon10C>T [OR 15.34, 95%CI (7.55-31.55)] and CG at codon25G>C (100%) were overrepresented (p<0.001). CC haplotype of TGF-β was overrepresented in patients [(OR 6.86, 95%CI (3.88-12.21), p<0.001)].
Conclusions: Considering higher frequencies of specific genotypes of both IL-4 and TGF-β in patients with AD, the gene polymorphisms of these cytokines could confer susceptibility to AD.
Keywords of your Abstract : Interleukin-4, Transforming Growth Factor-Beta, Single Nucleotide Genes Polymorphisms, Atopic Dermatitis
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/16154/Forms/306/Acceptance_1.doc
The presentation : Poster
The Cover of Abstract book :
Published abstract in the abstract book with the related code :
Where has your abstract been indexed? : ISI
If you choose other, please name :  
The Congress Reporting Form
How many volunteers were present at the Congress? : > 8000
Delegates from which countries presented in the congress? : Many countries worldwide, especially USA, UK, Australia, Canada, etc
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : AAAAI, EAACI, ESID, ERS
What were the responses to your talking points? Were specific questions or concerns raised? : More than 20 queries were made which were answered well. The comments on further collaboration were as of mutal interest.
If you met staff members, please list their full names & positions. : Hans Ochs (Univ Washington), Charlotte Cunningham-Rundles (Mount Sinaii), William Shearer (Texas Children's Hospital), Kate Sullivan (University of Pensilvania), Tony Bonilla (Harvard Medical School), Jennifer Puck (UCSF)
Please inform us if there are any follow up actions we need to talk with the members of the congress : -No-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Your experiences about the travel processes(Providing ticket, accommodation,...) : Booking the hotel was difficult, as we do not access to any kind of credit card!
Please give a briefing of your own observations and outcomes of the congress: : - Presenting poster in the poster session was one of the main goals.///
- I had the chance to attending several sessions.
I as an active member of the PID committee of the AAAAI has the chance to attend this policy making committee for the first time.///
- The PID committee of WAO was organized for the first time, as I am proud to be a member of this new committee.///
- I also attended the USIDNET session.///
- Attending the key note lecture sessions, oral sessions, and interactive panels were also part of the activities in this meeting. ///