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Abstract(Please copy/paste the abstract send to the congress) : |
Level of new adipocytokine, Adipose triglyceride lipase (ATGL), as an immune related factor in normal weight and obese patients under hemodialysis
Hosseinzadeh-Attar MJ(a), Alipoor E(a), Mahdavi-Mazdeh M(b), Yaseri M (c)
(a) Department of clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran;
(b) Iranian Tissue Bank & Research Center, Tehran University of Medical Sciences, Tehran, Iran;
(c) Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;
Background
The obesity epidemic has been represented as a major public health problem with widespread clinical consequences. Obesity induced inflammation and impaired immune function are among the most remarkable complications. On the other hand, there are limited data examining the probable role of obesity and adipose tissue on immune function in pathophysiological conditions such as advanced kidney insufficiencies, which are accompanied with considerable innate and adaptive immune dysfunction. A recently recognized adipokine, Adipose triglyceride lipase (ATGL), has been proposed to play a role in immune function and inflammation. ATGL mRNA is expressed in adipose tissue and to a lower extent in peritoneal macrophages, monocyte-derived macrophages and foam cells. It has been reported that ATGL levels are lower in overweight and obese subjects compared to normal weight group in normal population. Thus, it is assumed that ATGL could play a role in determining obesity related immune dysfunction. However, there is little evidence in this field. The aim of the current study was to investigate serum levels of ATGL and hs-CRP in two groups of normal weight and obese patients under hemodialysis.
Methods
The fasting serum levels of ATGL and hs-CRP were assessed in 44 patients with normal weight (BMI<25kg/m2) and 44 obese (BMI≥30kg/m2) who were under regular hemodialysis three days a week for at least 6 months.
Results
Although the serum levels of ATGL were lower (10.04±8.1 vs. 10.42±5.89mIU/mL) and hs-CRP levels were higher (9.4±7.9 vs. 6.8±6.9mg/dL) in obese group, they were not statistically different between two groups (P=0.481 and P=0.202 respectively). Moreover, no significant correlation was observed between ATGL and anthropometric indexes including BMI, weight and waist circumference.
Conclusion
Based on our findings, in contrary to normal population, immune related factors such as ATGL and hs-CRP were not significantly different between normal weight and obese patients under hemodialysis. Furthermore, unexpectedly, the levels of ATGL did not reflect the adipose tissue content in this condition. Therefore, it seems that metabolic alterations due to uremic condition have dominant role compared to obesity in determining immune parameters in hemodialysis. Further studies are required to clarify the precise role of adipose tissue on immune function in pathophysiological conditions such as uremia. |