Tehran University of Medical Sciences
Office of Vice-Chancellor for Global Strategies & International Affairs
International Human Capacity Development (IHCD)
Code : 9822-350309      Publish Date : Tuesday, September 15, 2015 Visit : 2069

Intl. Congress form | International Congress Report | International Congress Report For Students and Staff | RICT 2015, Drug Discovery and Selection Understanding Targets and Mechanisms 51st International Conf...

RICT 2015, Drug Discovery and Selection Understanding Targets and Mechanisms 51st International Conference on Medicinal Chemistry
The report of RICT 2015, Drug Discovery and Selection Understanding Targets and Mechanisms 51st International Conference on Medicinal Chemistry by Golnaz Rezaeizadeh
 
Application Code :
306-0215-0086
 
Created Date : Sunday, July 26, 2015 09:42:06Update Date : Tuesday, July 28, 2015 13:45:36
IP Address : 194.225.53.24Submit Date : Tuesday, July 28, 2015 13:46:00Email : golnaz_rezaei80@yahoo.com
Personal Information
Name : Golnaz
Surname : Rezaeizadeh
School/Research center : Maternal, Fetal and Neonatal Research Center (MFNRC)
If you choose other, please name your Research center :  
Position : staff
Tel : +98-21-66591316
Information of Congress
Title of the Congress : RICT 2015, Drug Discovery and Selection
Understanding Targets and Mechanisms
51st International Conference on Medicinal Chemistry
Title of your Abstract : A SYSTEMATIC REVIEW OF THE UTERINE RELAXANT EFFECT OF HERBAL SOURCES
Country : France
From : Wednesday, July 1, 2015
To : Friday, July 3, 2015
Abstract(Please copy/paste the abstract send to the congress) : Preterm birth is a worldwide tragedy with a high incidence. Several medications, are used to inhibit acute preterm labor; but tocolysis by these drugs do not extend pregnancy beyond 1-2 days. So new medications should be discovered for the treatment of preterm labor. For this purpose we reviewed all studies in which plant extracts or their effective materials inhibit the uterine contractions. All electronic databases were searched up to 1st February 2012 with the most relevant keywords. Studies related to the relaxant effect of plant extracts or their effective materials on the human or animal myometrium both in vivo and in vitro were included. Of initial search, 259 records were reviewed and finally, 72 were included. 

About the mechanism of these plant extracts or their effective materials we found that the nitric oxide pathway, unlike human myometrium, dose not play an important role in relaxation of pregnant and non-pregnant rat myometrium, but it probably acts on laboring rat myometrium. Another issue is about the store operated calcium entry (SOCE), a voltage independent calcium entry pathway, which is upregulated in late pregnant and active laboring rat myometrium and causes an increase in basal tone in these tissues, which is nifedipine resistant. In this review, agents which blocked agonist-induced myometrium contractions in a calcium free solution, probably acted via blocking the SOCE. SOCE can block by cyclic nucleotides. β-agonists and phosphodiesterase(PDE) inhibitors can increase the cyclic nucleotides, but unlike β-agonists which are desensitizing at the end of the pregnancy, PDE inhibitors can completely relax the pregnant myometrium. Studies have shown that some of the effective materials that were reviwed in this study(osthole, Naringenin, Kaempferol and quercetin) are PDE inhibitors.

Conclusion:It seems that laboring uterus responsiveness to different tocolytics vary from non-laboring uterus, so further studies should work on the pharmacology of the laboring uterus and evaluated the effect of these PDE inhibitor materials on blocking the SOCE, in human laboring myometrial cells and also determine the structure activity relationship of these tocolytic compounds.

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Keywords of your Abstract : Evidence-based medicine, natural products, systematic review, uterine, relaxant effect.
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/25545/Forms/306/acceptance_1.pdf
The presentation : Poster
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/25545/Forms/306/1_2.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/25545/Forms/306/113_2.pdf
Where has your abstract been indexed? : other
If you choose other, please name : abstract book of symposium
The Congress Reporting Form
How many volunteers were present at the Congress? : about 500 scientists
Delegates from which countries presented in the congress? : All around the world but mostly european countries.
for example: spain, france, USA, Germany, China, Japan
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box :  
What were the responses to your talking points? Were specific questions or concerns raised? : There weren't any unclear or obscure points in my poster presentation and there was no specific question about my work but it was a very enjoyable experience for me.Firstly I concerned about the language but everybody there have the same problem.
If you met staff members, please list their full names & positions. : I did not met any staff member. I just do the rutines.
Please inform us if there are any follow up actions we need to talk with the members of the congress : I think there is no need for following up actions, the members of the congress were so kind and also they were so polite. They are also in contact with the participants after ending the congress and answer all the participents questions very very politely. their manner were wondeful.they also accept that I pay the fee on-site. they send me the invitation letter before paying the fee and also before accepting my abstract.
Your experiences about the travel processes(Providing ticket, accommodation,...) : I think the people of other countries especially european countries behave more politer than us and comply with the rules.
Please give a briefing of your own observations and outcomes of the congress: : It was my first poster presentation experience. I think taking part in such congresses can improve our knowledge and can help us to do scientific projects with other countries but the cost of these congresses are high for our scientists. The participants only know our very famous scientists such as prof. Abas Shafiee a professor of medicinal chemistry in Iran but not the young scientists. It seems that supporting the young scientist of our country can help to them to be recognized by the scientists of other countries.