Tehran University of Medical Sciences
Office of Vice-Chancellor for Global Strategies & International Affairs
International Human Capacity Development (IHCD)
Code : 9822-350310      Publish Date : Tuesday, September 15, 2015 Visit : 2601

Intl. Congress form | International Congress Report | International Congress Report For Students and Staff | International student congress of biomedical sciences (ISCOMS 2015)

International student congress of biomedical sciences (ISCOMS 2015)
The report of International student congress of biomedical sciences (ISCOMS 2015) by Ghazal Sadat Fatemi Nasab
 
Application Code :
306-0215-0083
 
Created Date : Saturday, May 23, 2015 10:10:59Update Date : Tuesday, August 18, 2015 12:53:43
IP Address : 194.225.57.25Submit Date : Tuesday, August 18, 2015 12:54:43Email : ghazalsadat@yahoo.com
Personal Information
Name : Ghazal Sadat
Surname : Fatemi Nasab
School/Research center : School of Public Health
If you choose other, please name your Research center :  
Position : staff
Tel : +98-21-88962343
Information of Congress
Title of the Congress : International student congress of biomedical sciences (ISCOMS 2015)
Title of your Abstract : Analysis of titers of protective antibodies against circulating genotypes (H1, B3 and D4) of measles virus in Iran
Country : Afghanistan
From : Sunday, May 31, 2015
To : Saturday, June 6, 2015
Abstract(Please copy/paste the abstract send to the congress) : Introduction: 
Measles is a leading cause of morbidity and mortality in children globally. Despite the accessibility of a promising measles virus (MV) vaccine measles outbreaks take place even in well vaccinated populations. From all 24 known genotypes of MV, D4, H1 and B3 have been detected regularly from different regions in Iran. It is necessary to evaluate the protective efficacy of vaccine against currently circulating MV genotypes. A widely accepted standard method for measuring functional neutralizing antibodies is plaque reduction neutralization (PRN) test. Despite its greater sensitivity the conventional PRN test is laborious and time-consuming. For this reason, we have developed a microneutralization test to detect virus growth in plates after virus neutralization.

Materials & methods: 
We measured the neutralizing antibody titers against different genotypes of MV, such as H1, D4, B3 and vaccine strain (A) by micro-neutralization assay in 12 children after 2 months of vaccination. 

Results: 
The results indicate that the vaccine strain had a neutralization activity against H1 and D4 but wasn't competent enough to neutralize B3. In all samples, the neutralization activity against B3, H1, D4 and A was reported 25%, 75%, 67% and 66%, respectively. Another prominent result of our study was demonstration of a marked difference in plaque size by the strains tested. Significant difference between genotype B3 with genotype D4 and marked significant differences with H1 genotype was observed. 

Discussion: 
Lowest antibody response was against genotype B3 and the highest response with negligible differences was observed with genotype H1. Since the size of B3 plaque had no significant differences compared to the vaccine strain, so the diameter of plaque may not be indicative of the pathogenicity of the virus. Therefore further research is needed to compare the expression of HSPs in the vaccine strain and B3 genotypes and their relationship with their plaque size. 
Conclusion: 
Even though our study investigated only a limited number of individuals, the data showed more appropriate response of D4 and H1 genotypes to current vaccine. Further molecular studies on the hemagglutinin and fusion proteins of measles virus is needed for understanding the differences observed in response to measles vaccine. 
Keywords of your Abstract : Measles virus, Micro-neutralization, Genotypes, Iran
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/24865/Forms/306/Letter_of_Acceptance_iedereen_181.pdf
The presentation : Oral
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/24865/Forms/306/PDF_BOOK.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/24865/Forms/306/PDF_Article.pdf
Where has your abstract been indexed? : none
If you choose other, please name :  
The Congress Reporting Form
How many volunteers were present at the Congress? : 400 Approximately
Delegates from which countries presented in the congress? : All around the world
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : Different Universities from all around the world:such as Netherlands-India-Pakistan-Sweden and Italy.
What were the responses to your talking points? Were specific questions or concerns raised? : My presentation was positively received and the audience were extremely happy about the high level of immunization in Iran
If you met staff members, please list their full names & positions. : Joost Beusekamp, Arlette Kuik, Piter Huisma
Please inform us if there are any follow up actions we need to talk with the members of the congress : none.................................................................................................................................................................................................................................................................................................................................................................................................................................................................
Your experiences about the travel processes(Providing ticket, accommodation,...) : The process of payment was hard because of sanctions but the registration process was simple and straight forward
Please give a briefing of your own observations and outcomes of the congress: : It was extremely professional and scientific and I really enjoyed and learnt a lot by attending this congress. The congress was very well planned and we were busy throughout the congress days. The lectures were really useful and high level and performed by top level scholars. The congress staff were really welcoming and helpful. Overall all, It was an extremely unique and educational experience and I hope we can manage similar congresses here and attract researchers from all over the world to come and share their ideas in order to improve our own academic level.