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Title of the Congress : |
29th Annual Congress of the European Association of Nuclear Medicine. |
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Title of your Abstract : |
Comparison of sensitivity and specificity of Tc-99m octreotide and I-131 MIBG scintigraphies in diagnosis and localization of pheochromocytoma and neuroblastoma |
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Destination Country : |
Spain |
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From : |
Saturday, October 15, 2016 |
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To : |
Wednesday, October 19, 2016 |
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Abstract(Please copy/paste the abstract send to the congress) : |
Comparison of sensitivity and specificity of Tc-99m octreotide and I-131 MIBG scintigraphies in diagnosis and localization of pheochromocytoma and neuroblastoma
A. Fard-Esfahani, A. Emami-Ardekani, A. Mirzabeigi, B. Fallahi, A. Hassanzadeh-Rad, D. Beiki, P. Geramifar, M. Eftekhari;
Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IRAN, ISLAMIC REPUBLIC OF.
Abstract
Introduction: Tc-99m octreotide scan and I-131 metaiodobenzylguanidine (MIBG), are both valuable agents in diagnosis and localization of neuroendocrine tumors. This study was performed to compare the sensitivity and specificity of these agents in detection of pheochromocytoma and neuroblastoma. Materials and methods: 40 patients with pathologically proven pheochromocytoma/neuroblastoma were enrolled and octreotide and MIBG scans were performed for every patient. A composite reference standard consisting of cytopathology, biomarkers, anatomical imaging and six-month follow-up data was used as a reference for final diagnosis to evaluate the scintigraphic imaging results. Lesion-based and patient-based analysis were performed. Findings: On the basis of lesion-based analysis, overall sensitivity of MIBG was better than octreotide study (94.44% vs 80.56%). Cosidering each disease separately, sensitivity of both scans for pheochromocytoma was 100 %, but MIBG study showed a higher specificity (%100) than octreotide (87.5%). In neuroblastoma, MIBG sensitivity (100%) was better than octreotide (81.25%); however specificity was higher with octreotide study (100% for octreotide versus 92.85% for MIBG). On the basis of patient-based analysis, MIBG had equal sensitivity and specificity of 100 % for both diseases. Although octreotide also had 100 % sensitivity for pheochromocytoma, its specificity was 87.50%. For neuroblastoma, octreotide study had 81.25% sensitivity and 100 % specificity. Conclusion: Both MIBG and octreotide scans show high sensitivity and specificity in detection of neuroendocrine tumors of pheochromocytoma and neuroblastoma. However, MIBG scan with its better sensitivity may be considered the first line functional imaging modality; octreotide can be used to provide complementary information. It is advisable that if any of these two scans becomes negative in a patient with high clinical suspicion, the other one is performed, so that no useful data is missed in patientÂ’s management. |
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Keywords of your Abstract : |
octreotide, somatostatin receptor, neuroblastoma, pheochromocytoma |
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Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/27807/Forms/306/Accepted abstract EANM 2016 Barcelona_1.pdf |
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The presentation : |
eposter |
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The Cover of Abstract book : |
http://gsia.tums.ac.ir/images/UserFiles/27807/Forms/306/EANM-2016_Cover_Abstract_Book.PDF |
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Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/27807/Forms/306/PDF_abstract_2016_EANM_Barcelona_with_code.pdf |
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Where has your abstract been indexed? : |
ISI |
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If you choose other, please name : |
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