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Title of the Congress : |
“10th International Conference on Neuroscience and Neurochemistry 2017” |
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Title of your Abstract : |
“Minocycline Attenuates Depressive‐Like Behaviour Induced by Rat Model of Testicular Torsion: Involvement of Nitric Oxide Pathway” |
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Destination Country : |
Netherlands |
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From : |
Monday, February 27, 2017 |
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To : |
Tuesday, February 28, 2017 |
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Abstract(Please copy/paste the abstract send to the congress) : |
Testicular torsion/detorsion (T/D) can induce depression in pre- and post-pubertal patients. This study was conducted to investigate the psychological impact of testicular torsion and mechanism underlying its depressive-like behaviour, as well as antidepressant-like activity of minocycline and possible involvement of nitric oxide (NO)/cyclic GMP pathway in this paradigm in male rats undergoing testicular T/D. Unilateral T/D was performed in 36 male adult Wistar rats, and different doses of minocycline were injected alone or combined with Nx-nitro-L-arginine methyl ester (L-NAME), non-specific NO synthase (NOS)inhibitor; aminoguanidine (AG), specific inducible NOS inhibitor;L-arginine, an NO precursor; and selective PDE5I, sildenafil. After assessment of locomotor activity in open-field test, immobility times were recorded in the forced swimming test (FST). Moreover, 30 days after testicular T/D, testicular venous testosterone and serum nitrite concentrations were measured. A correlation was observed between either a decrease in plasma testosterone or an increase in serum nitrite concentrations with prolongation in immobility time in the testicular T/D-operated rats FST. Minocycline (160 mg/kg) exerted the highest significant antidepressant-like effect in the operated rats in the FST (p<0.001). Furthermore, combination of subeffective doses of minocycline (80 mg/kg) and either L-NAME (10 mg/kg) or AG (50 mg/kg) demonstrated a significant robust antidepressant-like activity in T/D group (p<0.01). Consequently, NO/cGMP pathway was involved in testicular T/D-induced depressive-like behavior and antidepressant-like activity of minocycline in the animal model. Moreover, a contribution was observed between either decreased testosterone or elevated serum nitrite levels and depressive-like behaviour following testicular T/D. |
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Keywords of your Abstract : |
Minocycline , Depressive‐Like, Testicular Torsion, Nitric Oxide , Rat |
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Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/36129/Forms/306/acceptance holand_2.pdf |
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The presentation : |
Oral |
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The Cover of Abstract book : |
http://gsia.tums.ac.ir/images/UserFiles/36129/Forms/306/ax jeld_1.pdf |
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Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/36129/Forms/306/kholase_maghale.pdf |
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Where has your abstract been indexed? : |
other |
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If you choose other, please name : |
Chemical Abstracts Service (CAS), Index Copernicus, Google Scholar ,Sherpa Romeo ,Open J Gate |