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Abstract(Please copy/paste the abstract send to the congress) : |
The effect of vitamin D supplementation on breast density changes: A clinical trial study
Running title: vitamin D supplementation on breast density
Sadaf Alipour 1,2, Azin Saberi2, Leila Bayani 3, Nooshin Shirzad 4,5, Mahdi Sepidarkish 6 , Ladan hosseini 7
1- Vali-e-Asr Reproduction Health Research Center, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Surgery, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Radiology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
4- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
5- Endocrine Research Center, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran
6- Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
7- Research Development Center, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
ABSTRACT
Background:
Previous evidence suggests that vitamin D reduces the incidence and mortality of breast cancer. The aim of this study was to determine the effect of supplementation with 50,000IU/monthly vitamin D for one year on breast density in Iranian women.
Methods: This double-blind, placebo-controlled, single center clinical trial was conducted among 500 women aged 40 years and older. Participant were allocated to two groups. Group 1 received vitamin D 50,000 IU in tablet form, monthly, for one year. Group 2 received vitamin E 400 IU in tablet form, for the same period of time. Participants had follow up clinic visits every six months and received an annual mammogram.
Results: Final data were evaluated based on 216 and194 women in the treatment and control groups. The mean decrease in mammographic density was -5.01 %( 95% CI, -9.9% to -0.01%) and -2.34 %( 95% CI, -6.84% to -2.15%) in the treatment and control groups, respectively. There was no significant association between vitamin D consumption and breast density after one year (OR=0.7, 95% CI, 0.46 to 1.06; P=0.1). Similar results were observed when multivariate model of logistic regression analysis was performed and vitamin D consumption was not significantly associated with breast density, independent of other variables (OR=1.07.95% CI, 0.58 to 1.96; P=0.8).
Discussion: This study showed that monthly consumption of 50,000 IU of vitamin D supplementation for one year did not effect on breast density. |