Tehran University of Medical Sciences
Office of Vice-Chancellor for Global Strategies & International Affairs
International Human Capacity Development (IHCD)
Code : 9345-338791      Publish Date : Tuesday, June 17, 2014 Visit : 2013

Intl. Congress form | International Congress Report | International Congress Report For Faculty | The 2nd INTERNATIONAL CONFERENCE ON HEART & BRAIN

The 2nd INTERNATIONAL CONFERENCE ON HEART & BRAIN
The 2nd INTERNATIONAL CONFERENCE ON HEART & BRAIN by Dr.seyed ali keshavarz
Application Code :
306-0114-0040
 
Created Date : Sunday, May 11, 2014 11:19:38Update Date : Monday, June 02, 2014 12:51:35IP Address :192.168.65.158
Submit Date : Sunday, May 25, 2014 10:34:27Email : s_akeshavarz@yahoo.com
Personal Information
Name : seyed ali
Surname : keshavarz
School/Research center : School of Nutrition Sciences and Dietetics
If you choose other, please name your Research center :  
Possition : Professor
Tel : +98-21-88955975
E-mail : s_akeshavarz@yahoo.com
Information of Congress
Title of the Congress : The 2ndINTERNATIONAL CONFERENCE ON HEART & BRAIN
Title of your Abstract : INFLUENCE OF VITAMIN A SUPPLEMENTATION ON CYTOKINES GENE EXPRESSION THAT SECRETED BY TCD4+ LYMPHOCYTES IN ATHEROSCLEROTIC PATIENTS
country : france
From : Thursday, February 27, 2014
To : Saturday, March 01, 2014
Abstract(Please copy/paste the abstract send to the congress) : INFLUENCE OF VITAMIN A SUPPLEMENTATION ON CYTOKINES GENE EXPRESSION THAT SECRETED BY TCD4+ LYMPHOCYTES IN ATHEROSCLEROTIC PATIENTS 
S.A. Keshavarz, A.A. Saboor-Yaraghi, A. Mottaghi, K. Mirzaei
School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Aim 
Atherosclerosis is an inflammatory arterial wall disease and T lymphocytes have important role in the pathogenesis and progression of this disease. The aim of this study is determination of vitamin A supplementation effects on gene expression of cytokines secreted by TCD4+ lymphocytes in atherosclerotic patients.
Methods and Materials: Thirty one atherosclerotic patients and 12 healthy controls participated in this study. Vitamin A supplement was given as retinyl palmitate; 25000 IU per day. After the intervention period the gene expression pattern of relevant cytokines of CD4+ T cells including Th1, Th2, Th17 and Treg were determined by Real-Time PCR from peripheral blood mononuclear cells. 
Results: Vitamin A increased proliferation of cells that stimulated with ox-LDL in all groups. Results of this study show that IFN-y and T- bet gene expression in fresh cells in vitamin A-treated patients was decreased (0.85 fold, P=0.068 and 0.39 fold, P=0.0001; respectively). The IL-4 gene expression were increased 12.7 fold (P=0.0001). 2.9 fold (P=0.323) and 3.5 fold (P=0.009) in vitamin A-treated patients, patients who received placebo and healthy controls respectively. IL-17 gene expression in fresh cells of vitamin A-treated patients were diminished (0.63 fold, P=0.003).
Gene expression of RORc in PHA-activated cells in vitamin A-treated patients and healthy controls was decreased (0.87 fold. P=0.015 and 0.72 fold, P=0.022; respectively) but in patients who received placebo was elevated (1.17 fold, P=0.019) in this gene expression was seen. Foxp3 gene expression in fresh cells was increased after intervention in all groups (Vitamin A-treated patients 10.1 fold (P=0.0001), patients who received placebo 1.9 fold (P=0.254) and healthy controls 5.6 fold (P=0.0001).
Conclusion: Increase in gene expression of Th2 cells was seen in all group expect GATA3 gene. According to the results of how the effect of vitamin A on gene expression in atherosclerotic patients, perhaps we thought the positive role of vitamin A supplementation in these patients. Results of this study could pave the way for a more detailed review on effect of vitamin A in patients with immune related diseases.
Keywords of your Abstract : Atherosclerosis, vitamin A supplementation, TCD4+ lymphocytes
Acceptance Letter :
The presentation : eposter
The Cover of Abstract book :
Published abstract in the abstract book with the related code :
Where has your abstract been indexed? : none
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The Congress Reporting Form
How many volunteers were present at the Congress? : about 500
Delegates from which countries presented in the congress? : USA- china-Jepan-Spain-German
Were the delegates of any other organizations present in the congress? : No
If yes, please write the names of the organizations in the box :  
What were the responses to your talking points? Were specific questions or concerns raised? : There was no important questions. The audience gave me good reflex and 
I earned good experience. I will improve my next searches.
If you met staff members, please list their full names & positions. : I did not see any stuff
Please inform us if there are any follow up actions we need to talk with the members of the congress : I think everything was ok. Because the congress happened in that hotel I was. I could communicate with other guess and see them easily. Congress was holding perfect and I am satisfied because joining there. The time tables were exactly designed and the arrangement was really perfect. I hope this type of congress happen in Iran in future.
Your experiences about the travel processes(Providing ticket, accommodation,...) : I suggest that a visa office should be conduct on TUMS
Please give a briefing of your own observations and outcomes of the congress: : The aim of my study was determination of vitamin A supplementation effects on gene expression of cytokines secreted by TCD4+ lymphocytes in atherosclerotic patients.Because the congress happened in that hotel I was, I could communicate with other professors and see them easily.I am satisfied because of joining there. and the arrangement was really perfect. This type of congress can be useful for our researches. . I think we can hold congress and seminars like this and invite professors. Therefore our researchers can relate with other universities and learn more of them.