Title of the Congress : |
9th Europian congress of tropical medicine and international health |
Title of your Abstract : |
Evaluation of Toxoplasma gondii soluble, whole and excretory/secretary antigens for detection of toxoplasmosis by ELISA test |
Country : |
Switzerland |
From : |
Sunday, September 6, 2015 |
To : |
Thursday, September 10, 2015 |
Abstract(Please copy/paste the abstract send to the congress) : |
Evaluation of Toxoplasma gondii soluble, whole and excretory/secretary antigens for detection of toxoplasmosis by ELISA test
S. Shojaee *.S. Pishkari, H. Keshavarz, M. Salimi, M. Mohebali
School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Corresponding author: shojaee1980@yahoo.com
The present study was performed to compare the soluble, whole and excretory/secretary antigens of Toxoplasma gondii (RH strain) in diagnosis of toxoplasmosis by ELISA method.
Tachyzoites of T.gondii, RH strain were injected in intra-peritoneal cavity of BALB/c mice, after 4 days tachyzoites were harvested by peritoneal washing of the mice. For soluble antigen, exudates were centrifuged and sediment sonicated and then centrifuged at 4ºC, 1hr, supernatant collected and density of protein determined by Bradford method. For whole antigen after collecting, washing and centrifuging of peritoneal fluid the tachyzoites sediment was counted. In excretory/secretary antigen 1.5 × tachyzoites were transferred in 1ml tube of saline and incubated under mild agitation and after centrifuging, supernatant was collected and protein density determined by Bradford method.
176 human serum samples were evaluated for T.gondii IgG antibody with prepared antigens, and finally serum samples were evaluated by commercial ELISA kit (Trinity,USA) which was considered as gold standard method.
In this study sensitivity and specificity of prepared antigens compared with commercial kit in ELISA method. Sensitivity and specificity of soluble antigen was 91.4% and 74.5%, in whole antigen these parameters were 77.1% and 77.3% and in excretory/secretary antigen were 28.5% and 74.5% respectivly.
Soluble antigen had high levels of sensitivity and specificity in ELISA method and the results were rather resemble to commercial kit (Trinity,USA).
Key words: Toxoplasmosis, ELISA, Toxoplasma gondii, Soluble antigen, Whole antigen, Excretory/secretary antigen.
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Keywords of your Abstract : |
Toxoplasmosis, ELISA, Toxoplasma gondii, Soluble antigen, Whole antigen, Excretory/secretary antigen |
Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/21831/Forms/306/On_Tuesday.pdf |
The presentation : |
Poster |
The Cover of Abstract book : |
http://gsia.tums.ac.ir/images/UserFiles/21831/Forms/306/You_have_free_access_to_this_content.pdf |
Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/21831/Forms/306/abs_book.pdf |
Where has your abstract been indexed? : |
ISI |
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