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Intl. Congress form | International Congress Report | International Congress Report For Faculty | 4th European Congress of Immunology (ECI) Vienna 2015

4th European Congress of Immunology (ECI) Vienna 2015
The report of 4th European Congress of Immunology (ECI) Vienna 2015 by Dr. Maryam nourizadeh
Application Code :
306-0215-0114
 
Created Date : Sunday, October 11, 2015 14:26:26Update Date : Monday, October 19, 2015 13:19:34
IP Address : 194.225.212.150Submit Date : Monday, October 19, 2015 13:19:56Email : mnourizadeh@sina.tums.ac.ir
Personal Information
Name : Maryam
Surname : Nourizadeh
School/Research center : Immunology, Asthma and Allergy Research Institute (IAARI)
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Position : Assistant professor
Tel : +98-21-66907415
Information of Congress
Title of the Congress : 4th European Congress of Immunology (ECI) Vienna 2015
Title of your Abstract : ‘A new IL-2RG gene mutation in an x-linked SCID identified through TREC/KREC screening: a case report’
Destination Country : Austria
From : Sunday, September 6, 2015
To : Wednesday, September 9, 2015
Abstract(Please copy/paste the abstract send to the congress) : Severe combined immunodeficiencies (SCID) represent a rare group of primary immunodeficiency disorders (PIDs), which will be fatal in early childhood due to development of common and opportunistic infections. Owing to a high number of unknown mutations in related genes especially in the exons of IL-2RG gene, new cases are intermittently reported around the world. Here, we found a new mutation of the common gamma chain in an Iranian X-SCID newborn.
The patient was a 6-day old boy with a family history of PID who was referred to the Immunology, Asthma and Allergy Research Institute (IAARI) for immunological evaluation. The child was screened using a molecular-based analysis that measures the number of copies of T cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) using a multiplex quantitative Real Time PCR. To confirm the results, a complete immunological evaluation and IL2RG (interleukin 2 receptor, gamma) gene sequencing were performed (both molecular assessment and gene sequencing were done in Leipzig, Germany).
The results of the multiplex quantitative real time PCR showed undetectable TREC but a high level of KREC copy numbers. Flow cytometric analysis of lymphocyte subsets also showed low numbers of T and NK cells, but elevated number of B cells. We subsequently found a novel substitution in the IL2RG encoding gene (X-SCID): c.675 C>A, leading to p.225 Ser>Arg. Based on the functional analysis using PolyPhen, the mutation is predicted to be damaging. The patient was thus diagnosed as a T- B+ NK- X-linked SCID.
Keywords of your Abstract : x-linked SCID ; IL-2RG mutation ; TREC/KREC
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/26835/Forms/306/Acceptance letter_2.pdf
The presentation : Poster
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/26835/Forms/306/Cover_of_Abstract_book.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/26835/Forms/306/My_abstract.pdf
Where has your abstract been indexed? : none
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The Congress Reporting Form
How many volunteers were present at the Congress? : 2500
Delegates from which countries presented in the congress? : Germany, Poland, France, Russia, Turkey, Italy,...
Were the delegates of any other organizations present in the congress? : No
If yes, please write the names of the organizations in the box :  
What were the responses to your talking points? Were specific questions or concerns raised? : One of the major point of my poster presentation was to find a SCID newborn using TREC/KREC screening method by quantitative multiplex Real Time PCR technique.
If you met staff members, please list their full names & positions. : I did not have any meeting with the staff and it was just for the registration process and CME credits.
Please inform us if there are any follow up actions we need to talk with the members of the congress : The results of the multiplex quantitative real time PCR showed undetectable TREC but a high level of KREC copy numbers. We subsequently found a novel substitution in the IL2RG encoding gene (X-SCID): c.675 C>A, leading to p.225 Ser>Arg. Based on the functional analysis using PolyPhen, the mutation is predicted to be damaging. The patient was thus diagnosed as a T- B+ NK- X-linked SCID.
Your experiences about the travel processes(Providing ticket, accommodation,...) : That was excellent. No problem has happened to me.
Please give a briefing of your own observations and outcomes of the congress: : The most important focus of lectures was on using immune cells especially T cells and dendritic cells for cancer immunotherapy. Also, it was so surprising that a lot of studies designed to do from bench to beside. It means that in such a multicenter projects, scientists try to perform the experimental research study and subsequently use the results for clinical trial approaches. Also, I found that the same work that I've done for screening the immunodeficiency disorders especially SCID, has been designed to do in the other European countries.