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Abstract(Please copy/paste the abstract send to the congress) : |
Urinary Uric acid / Creatinine Ratio as a marker of mortality and unfavorable outcome in NICU admitted Neonates
Nariman Sh1 , Mosayebi Z2, Sagheb S3, Rastad H4,Hosseininodeh S5
1) Shahin Nariman, Assistant Professor o fNeonatology, Tehran University of Medical Sciences, Tehran, Iran.
2) Ziba Mosayebi ,Associate Professor of Neonatology, Tehran University of Medical Sciences, Tehran, Iran.
3)Setareh Sagheb, Assistant Professor ofNeonatology, Tehran University of Medical Sciences, Tehran, Iran.(* corresponding author)
4)Hadith Rastad,Research development center,Arash Hospital, Tehran University of Medical
5) Seyyedsaeed Hosseininodeh, Department of Pediatrics, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Sciences, Tehran, Iran.
Corresponding Author
Name:Dr. Shahin Nariman
Address:Tehran University of Medical Sciences,Enghelab Avenue,Tehran ,Iran.P.O.Box:1653915981,Tel:+98-9122387976.
Email:dr.shnariman@gmail.com
Abstract:
Objective: We presumed whether urinary uric acid/ creatinine (UUA/Cr) ratio can be a marker of mortality and adverse outcome in neonates which were admitted to NICU.
Methods: All preterm infants who were admitted to our NICU after birth from March 2014to April 2015were enrolled in prospective cohort study. UUA/Cr was measured during the first day of life. Severity of diseases(The need for high set up of mechanical ventilation, complications of prematurity,duration of stay in NICU) and neonatal death were considered as the final unfavorable outcome.The relationship between Log-transformation (Ln) urinary uric acid / creatinine ratio and Apgar score at the first and 5th minute of birth with duration of stay were analysed by using Linear regression. Statistical analysis was done by using STATA version 11 (STATA Corp, TX, USA). A P value<0.05 was considered of statistical significance.
Results : The total of 362 preterm infants with mean gestational age 32.7(±3.9) weeks were admitted to NICU of whom 64 (17.6%) had severe disease ,in which 43(11.8%) died. The mean UUA/Crratio were significantly higher in the admitted neonates (3.30±1.95 VS. 1.36±0.42 p value 0.0001). There are negative correlations between UUA/Cr ratio and 1- minute Apgar score( R: -0.17, P Value: 0.006) and 5- minute Apgar score(R: -0.19, P Value: 0.003). The 1- minute Apgar scores were negatively correlated with the outcome (OR=0.68; P<0.001) and the duration of stay (β =-0.28; P value <0.001).There is not significant correlation between 5- minute Apgar scores and outcome. There is a significant positive correlation between UUA/Cr ratio with the unfavorable outcome(OR= 1.24; CI %95:1.06 to 1.43,P value =0.006) and increasing the duration of stay(β =0.17; P value=0.009) .
Conclusion: Urinary uric acid/ creatinine ratio can be used as a simple , noninvasive parameter of the severity of diseaseand mortality in NICU admitted neonates.
Keywords: Urinary uric acid to creatinine ratio; mortality ; newborn; outcome. |