Tehran University of Medical Sciences
Office of Vice-Chancellor for Global Strategies & International Affairs
International Human Capacity Development (IHCD)
Code : 9345-353482      Publish Date : Saturday, October 14, 2017 Visit : 1592

Intl. Congress form | International Congress Report | International Congress Report For Faculty | WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES by. Dr. Zhila Maghbooli

WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES by. Dr. Zhila Maghbooli
WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES by. Dr. Zhila Maghbooli
Zhila Maghbooli | International Congress Form

Application Code :
762-0117-0010
 
Created Date : Monday, April 24, 2017-10:14 10:14:26Update Date : Sunday, October 8, 2017-14:31 14:31:19
IP Address : 194.225.213.12Submit Date : Wednesday, September 6, 2017-12:00 12:00:19Email : z-maghbooli@sina.tums.ac.ir
Personal Information
Name : Zhila
Surname : Maghbooli
School/Research center : Endocrinology and Metabolism Research Center (EMRI)
If you choose other, please name your Research center :  
Position : Assistant professor
Tel : +98-21-88220072
Information of Congress
Title of the Congress : WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES
Title of your Abstract : GLOBAL DNA METHYLATION AS A POSSIBLE MECHANISM FOR THE EFFECT OF
VITAMIN D IN BONE HEALTH
Destination Country : Italy
From : Thursday, March 23, 2017
To : Sunday, March 26, 2017
Abstract(Please copy/paste the abstract send to the congress) : Objective: The aim of this study was to determine the relationship between inter-individual global DNA
methylation and vitamin D levels in postmenopausal women with osteoporosis.
Material and methods:
The 5-methyl cytosine content was assessed by reverse phase high pressure liquid chromatography (RPHPLC)
of peripheral blood leukocytes obtained from postmenopausal women to determine individual
global DNA methylation status (Cm %). Dual X-ray absorptiometry (DXA) densitometer (Lunar 7164)
were used to assess BMD of three bone sites (total hip, femoral-neck, and spinal lumbar vertebras (L2-L4).
Each person was categorized based on The WHO osteoporosis criteria; osteoporosis (T score ≤ -2.5),
osteopenia (-2.5 < T score < -1) and normal (T score ≥ -1) in at least one region. Vitamin D levels were
measured using electrochemiluminescence assay. The serum vitamin D levels lower than 30ng/ml were
defined as vitamin D deficiency or insufficiency.
Results: A total of 150 postmenopausal women (40 persons with osteoporosis, 40 persons with osteopenia,
and 70 persons) - who had not any chronic disorders- were recruited in this study.
There was a negative significant correlation between DNA methylation levels and vitamin D levels
(r=-0.20, p=0.01) without any association with age (p=0.3).
There was significantly higher levels of DNA methylation in subjects with vitamin D deficiency
(5.32±0.58 vs. 3.98±0.17, respectively, p=0.01). In women with vitamin D deficiency, there was
significant negative relationship between DNA methylation levels and T-score and BMD value of spinal
lumbar region (L2-L4) (p=0.012, r=-0.38).
Conclusion: The findings of this study suggest that vitamin D levels could influence bone status through
epigenetic mechanisms specially DNA methylation. So that, global DNA hyper-methylation was associated with lumbar bone loss in patient with vitamin D deficiency.
Keywords of your Abstract : DNA Methylation, Vitamin D deficiency, Osteoporosis
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/27850/Forms/762/IOF_2017_poster_vitD_methyl.pdf
The presentation : Poster
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/27850/Forms/762/WCO17-AbstractBook.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/27850/Forms/762/Poster_325_from__WCO17-AbstractBook.pdf
Where has your abstract been indexed? : ISI
If you choose other, please name :  
The Congress Reporting Form
How many volunteers were present at the Congress? : 4082 delegates took part in the largest event in the field of osteoporosis, osteoarthritis, frailty and sarcopenia.
Delegates from which countries presented in the congress? : Delegates were form all countries specially Italy, Belgium, French, Swiss, UK
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : IOF, WOC, ESCEO
What were the responses to your talking points? Were specific questions or concerns raised? : No
If you met staff members, please list their full names & positions. : No
Please inform us if there are any follow up actions we need to talk with the members of the congress : No
Your experiences about the travel processes(Providing ticket, accommodation,...) : I have used booking.com to reserve hotel and airport.
Please give a briefing of your own observations and outcomes of the congress: : the congress focused on "Fracture risk assessment to target treatment, Effectiveness and cost-utility". and also "Who and when to treat in osteoporosis?". In the field of osteoarthritis, the participants focused on "What can we expect from biomarkers in osteoarthritis?"