Zhila Maghbooli | International Congress Form
![]()
Application Code :
762-0117-0010
Created Date : Monday, April 24, 2017-10:14 10:14:26Update Date : Sunday, October 8, 2017-14:31 14:31:19
IP Address : 194.225.213.12Submit Date : Wednesday, September 6, 2017-12:00 12:00:19Email : z-maghbooli@sina.tums.ac.ir
Personal Information
|
Name : |
Zhila |
|
Surname : |
Maghbooli |
|
School/Research center : |
Endocrinology and Metabolism Research Center (EMRI) |
|
If you choose other, please name your Research center : |
|
|
Position : |
Assistant professor |
|
Tel : |
+98-21-88220072 |
Information of Congress
|
Title of the Congress : |
WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES |
|
Title of your Abstract : |
GLOBAL DNA METHYLATION AS A POSSIBLE MECHANISM FOR THE EFFECT OF
VITAMIN D IN BONE HEALTH |
|
Destination Country : |
Italy |
|
From : |
Thursday, March 23, 2017 |
|
To : |
Sunday, March 26, 2017 |
|
Abstract(Please copy/paste the abstract send to the congress) : |
Objective: The aim of this study was to determine the relationship between inter-individual global DNA
methylation and vitamin D levels in postmenopausal women with osteoporosis.
Material and methods:
The 5-methyl cytosine content was assessed by reverse phase high pressure liquid chromatography (RPHPLC)
of peripheral blood leukocytes obtained from postmenopausal women to determine individual
global DNA methylation status (Cm %). Dual X-ray absorptiometry (DXA) densitometer (Lunar 7164)
were used to assess BMD of three bone sites (total hip, femoral-neck, and spinal lumbar vertebras (L2-L4).
Each person was categorized based on The WHO osteoporosis criteria; osteoporosis (T score ≤ -2.5),
osteopenia (-2.5 < T score < -1) and normal (T score ≥ -1) in at least one region. Vitamin D levels were
measured using electrochemiluminescence assay. The serum vitamin D levels lower than 30ng/ml were
defined as vitamin D deficiency or insufficiency.
Results: A total of 150 postmenopausal women (40 persons with osteoporosis, 40 persons with osteopenia,
and 70 persons) - who had not any chronic disorders- were recruited in this study.
There was a negative significant correlation between DNA methylation levels and vitamin D levels
(r=-0.20, p=0.01) without any association with age (p=0.3).
There was significantly higher levels of DNA methylation in subjects with vitamin D deficiency
(5.32±0.58 vs. 3.98±0.17, respectively, p=0.01). In women with vitamin D deficiency, there was
significant negative relationship between DNA methylation levels and T-score and BMD value of spinal
lumbar region (L2-L4) (p=0.012, r=-0.38).
Conclusion: The findings of this study suggest that vitamin D levels could influence bone status through
epigenetic mechanisms specially DNA methylation. So that, global DNA hyper-methylation was associated with lumbar bone loss in patient with vitamin D deficiency. |
|
Keywords of your Abstract : |
DNA Methylation, Vitamin D deficiency, Osteoporosis |
|
Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/27850/Forms/762/IOF_2017_poster_vitD_methyl.pdf |
|
The presentation : |
Poster |
|
The Cover of Abstract book : |
http://gsia.tums.ac.ir/images/UserFiles/27850/Forms/762/WCO17-AbstractBook.pdf |
|
Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/27850/Forms/762/Poster_325_from__WCO17-AbstractBook.pdf |
|
Where has your abstract been indexed? : |
ISI |
|
If you choose other, please name : |
|
The Congress Reporting Form
|
How many volunteers were present at the Congress? : |
4082 delegates took part in the largest event in the field of osteoporosis, osteoarthritis, frailty and sarcopenia. |
|
Delegates from which countries presented in the congress? : |
Delegates were form all countries specially Italy, Belgium, French, Swiss, UK |
|
Were the delegates of any other organizations present in the congress? : |
Yes |
|
If yes, please write the names of the organizations in the box : |
IOF, WOC, ESCEO |
|
What were the responses to your talking points? Were specific questions or concerns raised? : |
No |
|
If you met staff members, please list their full names & positions. : |
No |
|
Please inform us if there are any follow up actions we need to talk with the members of the congress : |
No |
|
Your experiences about the travel processes(Providing ticket, accommodation,...) : |
I have used booking.com to reserve hotel and airport. |
|
Please give a briefing of your own observations and outcomes of the congress: : |
the congress focused on "Fracture risk assessment to target treatment, Effectiveness and cost-utility". and also "Who and when to treat in osteoporosis?". In the field of osteoarthritis, the participants focused on "What can we expect from biomarkers in osteoarthritis?" |