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Abstract(Please copy/paste the abstract send to the congress) : |
Evaluation of plasma Lead concentration in osteoporotic patients by anodic stripping voltametry
Naficeh Sadeghia*, Mohammad Reza Oveisia,
Behrooz Jannatb, Mannan Hajimahmoodia, Abdolazim Behfarc, Masoomeh Behzada , Fatemeh Sadeghib , Golnaz Mohebzadeha
aDepartment of Drug and Food Control, School of Pharmacy, Tehran university of Medical Sciences, Tehran, Iran.
bFood and Drug laboratory research center, Ministry of Health and Medical Education, Tehran, Iran.
c Department of Drug and Food Control, Faculty of Pharmacy, Jondishapour Ahvaz University of Medical Sciences, Ahvaz, Iran
Abstract:
Background and aims:
Osteoporosis is a multifactorial disease with dimension of genetic, endocrine function, exercise and nutritional considerations. Of particular considerations are trace elements and toxic heavy metals such as Lead which may involve in an oxidative stress system. The aim of this study was to present data for the association of plasma Lead level with bone mineral density (BMD) in Iranian women.
Methods:
In this cross-sectional study, Participants (n=135) were selected by inclusion and exclusion criteria from those who were referred to Jamie Clinic in Tehran for BMD evaluation. Plasma samples of fasting blood withdrawal were analyzed for Lead concentration levels by anodic stripping voltametry method.
Results:
No differences were found in the nutritional status, number of diseases, drugs and functional activities between these groups. Total patients (TP, n=49; T-score<-1) were divided into mild patients (M; -1>T-score> -1.7), and severe patients (S; -1.7>Tscore).
Mean± SD plasma level of Lead was 168.42±9.61 ng/ml in control group (n=51; Tscore-1), 176.13±8.64 ng/ml in TP, 176.43±13.2 ng/ml in M patients and 221.44±20 ng/ml in S patient group, respectively. The results showed that: 1) plasma level of Lead was higher in patients with osteoporosis than in control, though it was not significant; 2) the difference was higher between control and group S who had more acute disease than group M who had milder disease; and finally 3) femoral neck T-score showed a negative and significant correlation with plasma levels of Lead in all participants (p<0.05, r = -0.201).
Conclusions:
It seems that Lead has a role in osteoporosis; which needs to more studies about the cellular-molecular mechanism or oxidative stress system.
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