Abstract(Please copy/paste the abstract send to the congress) : |
The Association between Androgenic Hormone Levels and the Risk of Developing Coronary Artery Disease (CAD)
Gholamreza Pourmand, MD, Farshad Namdari, MD,Farzad Allameh, MD-MPH,Abdol Rassoul Mehrsai, MD,Ali Bozorgi, MD Sepideh Nekuie, MD
Urology Research Center ,Tehran University of Medical Sciences ,Tehran, Iran
Objective: To evaluate the relationship between the serum levels of androgens and CAD in an Iranian population.
Methods: Male individuals who admitted Tehran Heart Center and Sina Hospital were categorized into CAD and control groups based on selective coronary angiography. Baseline demographic data, including age, BMI, diabetes, and a history of hypertension were recorded in the data collection form. Patients were also assessed for their serum levels of total testosterone, free testosterone, estradiol, Dehydroepiandrosterone Sulfate (DHEA-S) and Sex Hormone Binding Globulin (SHBG). Data analysis was carried out chi-square and ANOVA tests as well as logistic regression analysis.
Results: Two hundred patients were in the CAD group and 135 individuals were in the control group. In the CAD group, 69 had single-vessel disease, 49 had two-vessel disease, and 82 had three-vessel disease. Statistically significant differences were observed between the individuals in the two groups with respect to age (P<0.0001), diabetes (P<0.0001), and a history of hypertension (P=0.018). The serum levels of free testosterone (P=0.048) and DHEA-S (P<0.0001) were significantly higher in the control group than in the CAD group; however, the serum level of SHBG was higher in the CAD group than in the control group (P=0.007). Results of the logistic regression analysis indicated that only age (P=0.036) and diabetes (P=0.004) had significant relationships with CAD.
Conclusion: Although the serum levels of some of the androgens were significantly different between the two groups, no association was found between androgenic hormone levels and the risk of CAD, due mainly to the effect of age and diabetes.
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