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Code : 9822-332343 Created Date : Tuesday, December 24, 2013 Update Date : Wednesday, January 8, 2014 Visit : 3218

Asia Pacific Association of Medical Toxicology 12th International Congress

The Report of Asia Pacific Association of Medical Toxicology by mahnaz ahmadimanesh

Application Code :

306-0213-0075

Created Date : Sunday, October 06, 2013Update Date : Saturday, December 21, 2013IP Address :194.225.61.61
Submit Date : Monday, December 16, 2013Email : mahnaz_ahmadimanesh@yahoo.com

Personal Information

Name :	mahnaz
Surname :	ahmadimanesh
School/Research center :	School of Medicine
If you choose other, please name your Research center :
Possition :	student
Tel :	+98-915-5254102
E-mail :	mahnaz_ahmadimanesh@yahoo.com

Information of Congress

Title of the Congress :	Asia Pacific Association of Medical Toxicology 12th International Congress
Title of your Abstract :	Determination of tramadol and its major metabolites (M1, M2 and M5) concentration in plasma of human poisoning by HPLC and its relation with clinical symptoms
country :	Dobai
From :	Thursday, November 21, 2013
To :	Saturday, November 23, 2013
Abstract(Please copy/paste the abstract send to the congress) :	Tramadol hydrochloride is a novel synthetic opioid morphine like with a centrally acting analgesic effect. Tramadol produces analgesia by binding weakly to the µ-opioid receptor and inhibits reuptake of monoaminergic hormones (norepinephrine and serotonin). It is rapidly metabolized in the liver into O-desmethyl-tramadol (M1), N-desmethyl-tramadol (M2) and N,O-didesmethyl-tramadol (M5). CYP2D6 primarily is involved in M1 formation, CYP2B6 and 3A4 are involved in M2 formation and CYP 2D6, CYP 2B6 and 3A4 are involved in M5 formation. The CYP2D6 has high genetic polymorphism affecting the CYP enzymes in human and any co-ingested drug with potential effect on CYP2D6 such as tricyclic antidepressants, phenothiazines, and selective serotonin reuptake inhibitors may affect blood levels of M1. The pharmacological activity of M1 is most important and more potent at the µ -receptor than parent drug tramadol. The main and common side effects of tramadol include nausea, vomiting, vertigo, drowsiness, fatigue, sweating, dry mouth, and in over dose tachycardia, CNS depression, respiratory depression, seizure and coma. The serious side effect of tramadol may be depended to genetics, renal failure and metabolism. Although tramadol-related seizure may be happened with over dose, several reports showed that it could be occurred even at therapeutic doses. The exact cause and mechanism of induction of seizure in some users of tramadol remains unclear yet. In this study blood samples of 120 patients with a history of tramadol intoxication who were admitted in the emergency department of Logman Hakim Hospital were collected. Tramadol and its major metabolites (M1, M2, and M5) concentrations were measured by high performance liquid chromatography (HPLC) methods with ﬂuorescence detection. Furthermore tramadol and its major metabolites (M1, M2, and M5) concentrations were correlated with the main symptoms. Of all the symptoms, which were investigated, only seizure had significant correlation with respect to sex and increase concentration. Male patients had seizure significantly greater than females (p <0.001). It was also shown that the average concentration of M2 in male is significantly greater than female (p=0.003). Our results also indicates that there is a significant correlation between increased tramadol (p=0.006) and its metabolites (M1; p=0.017, M2; p=0.023, M5; p=0.011) concentrations in plasma with respect to seizure symptom. Also with increasing ratio of M1/M2, decreased in the risk of seizure (0.26-fold, p=0.02) was found. It is concluded that there might be a relationship between tramadol and its metabolites plasma concentrations with regard to sex and seizure. Also the risk of seizure increases with increasing concentration.
Keywords of your Abstract :	tramadol, major metabolites, clinical symptoms
Acceptance Letter :	http://gsia.tums.ac.ir/images/UserFiles/11668/Forms/306/acceptance_letter.pdf
The presentation :	Oral
The Cover of Abstract book :	http://gsia.tums.ac.ir/images/UserFiles/11668/Forms/306/scan book Copy_1.pdf
Published abstract in the abstract book with the related code :	http://gsia.tums.ac.ir/images/UserFiles/11668/Forms/306/scan_abstract_Copy.pdf
Where has your abstract been indexed? :	none
If you choose other, please name :

The Congress Reporting Form

How many volunteers were present at the Congress? :	I do not know exactly.
Delegates from which countries presented in the congress? :	Iran, Japan, USA, France, Norway, Canada, Malaysia, Oman, United Arabic Emirates, China, Australia, India, ...
Were the delegates of any other organizations present in the congress? :	No
If yes, please write the names of the organizations in the box :
What were the responses to your talking points? Were specific questions or concerns raised? :	They were very interesting subject to study. due to results were reported for the first time, the results presented also considered. The most important question was to consider in terms of tramadol pharmacokinetics and elapsed time between the occurrence of seizures (measured concentrations)
If you met staff members, please list their full names & positions. :	Reza Afshari president
Please inform us if there are any follow up actions we need to talk with the members of the congress :	No action is required to follow. I was present at the time designated by Congress in Congress. The lecture was presented and there was no follow-up. Some of our colleges talking with some of delegate regarding to invitation of them to participate and present their scientific lectures and also if their work are top in the field ,ask them to present their work in the plenary lecture sections
Your experiences about the travel processes(Providing ticket, accommodation,...) :	Only costs required to prepare for the trip was very difficult. In other cases, such as tickets and visas were easily
Please give a briefing of your own observations and outcomes of the congress: :	Congress was very good and high scientific level. It was a great experience for me. If every student has the opportunity to attend congresses can be very important for scientific studies, research projects and a great help to students. Financial problems and lack deprives students attending the Congress with the knowledge. it was interesting for me that our research work in our country is relatively update. Also researchers and clinicians from all over the world shared their latest findings, technical expertise and experiences that create a much-anticipated international event. This congress is held every years and is one of the most important meetings in the medical toxicology filed. I successfully participated in the 12th APAMT 21-23 November 2013, Dobai.

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