Code : 9345-336773      Created Date : Tuesday, May 6, 2014   Update Date : Tuesday, May 6, 2014    Visit : 2356

IANR VII, 1st SCSI, 11th GCNN and 2nd IFNR Conference

The Report of IANR VII, 1st SCSI, 11th GCNN and 2nd IFNR Conference by Dr.Hooshang Saberi
Application Code :
306-0114-0031
 
Created Date : Wednesday, March 19, 2014 12:02:50Update Date : Wednesday, April 30, 2014 14:46:29IP Address : 194.225.53.5
Submit Date : Wednesday, April 30, 2014 14:46:52Email : saberih@tums.ac.ir
Personal Information
Name : Hooshang
Surname : Saberi
School/Research center : ::Please Select::
If you choose other, please name your Research center : Brain and Spinal Injuries Research Center
Possition : Associate professor
Tel : +98-21-6658156
E-mail : saberih@tums.ac.ir
Information of Congress
Title of the Congress : IANR VII, 1st SCSI, 11th GCNN and 2nd IFNR Conference
Feb 27‐ Mar 1st (Mumbai, India)
Title of your Abstract : Efficacy of Granulocyte-Colony Stimulating Factor administration for Neurological Improvement in incomplete post-rehabilitated, spinal cord injuries: a Randomized Clinical Trial
country : India
From : Thursday, February 27, 2014
To : Saturday, March 01, 2014
Abstract(Please copy/paste the abstract send to the congress) : Efficacy of Granulocyte-Colony Stimulating Factor administration for Neurological Improvement in incomplete post-rehabilitated, spinal cord injuries: a Randomized Clinical Trial
Hooshang Saberi M.D., M.P.H
Nazi Derakhskanrad M.D., PHD.
Mirsaeed Yekaninejad PHD.
Brain and Spinal Injury Research Center
Tehran University of Medical Sciences, Tehran, Iran
Introduction:
Granulocyte-colony stimulating factor (G-CSF) is a major growth factor in the activation and differentiation of granulocytes. This cytokine has been widely and safely employed, in different conditions over many years. In this study we tried to administer the drug for spinal cord injury.
Methods:
Twenty four patients with spinal cord injury of at least six month duration were included into the study. Patients were assessed by ASIA, SCIM III and IANR-SCIFRS just before intervention and at six month after subcutaneous administration of 5µg/Kg of Granulocyte-Colony Stimulating Factor in the case group and placebo in the control group. Randomization was perfomed with random block design, the patients and evaluators were blinded in regard to the treatment group.This RCT was conducted on 24 traumatic SCI patients. Fourteen patients were studies in GCSF group and 10 patients in placebo group. The mean (SD) age of the patients in GCSF group was 36.64 (16.02) and 31.10 (11.34) in placebo group. About 86.0 % were male in GCSF group and 90% in placebo group. 
Results:
After 3 months of intervention ASIA Impairment Scale (AIS) in control group remained unchanged while in GCSF group 2 AIS C patients improved to AIS D. The mean improvement in ASIA motor score in GCSF group was 5.79 scores that was significantly higher than control group (0.5 scores) (P=0.01). The mean light touch and pin prick sensory scores increased by 5.50 and 4.14 scores in CCSF group and by 1.5 scores for both sensory indices in control group. Although the increment in sensory scores in GCSF group were higher than control group but there were not significant (P>0.10). Evaluation of functional improvement by FRS instrument revealed significantly higher improvement in GCSF group (2.07 scores) compared to the control group (0.10 scores) (P=0.001). However no significant difference in functional improvement between two groups observed by SCIM instrument (p=0.975).
Conclusion
Granulocyte-colony Stimulating Factor administration in incomplete spinal cord injuries is associated with significant motor improvement. Study in larger number of patients with longer follow up may be necessary to arrive at more detailed results.
Keywords of your Abstract : Spinal Cord Injury, Granulocyte-Colony Stimulating Factor, Neurological Restoration
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/17319/Forms/306/Hooshang Saberi_1.pdf
The presentation : Oral
The Cover of Abstract book :
Published abstract in the abstract book with the related code :
Where has your abstract been indexed? : none
If you choose other, please name :  
The Congress Reporting Form
How many volunteers were present at the Congress? : 500
Delegates from which countries presented in the congress? : USA, Canada, Sweden, Engeland, Jordan, India, China, Indonesia, Iraq, Iran, Romania
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : IANR VII, 1st SCSI, 11th GCNN and 2nd IFNR Conference
What were the responses to your talking points? Were specific questions or concerns raised? : yes, they recomended a multicenter clinical trials as joint collaboration between different research centers and various medical universities
If you met staff members, please list their full names & positions. : Hongyun Huang (China), Honorary President is Geoffrey
Raisman (UK) and other Presidents are Ziad M. Al Zoubi (Jordan) and Hari Shanker
Sharma (Sweden), Alok sharma(India), Russel Androws(USA),Gustav Moviglia(Argentina), Doffin Muriciano(Romania)
Please inform us if there are any follow up actions we need to talk with the members of the congress : Hopefully Iran and Tehran Univ. of Medical Sciences was sellected by the direct vote of IANR members to hold the upcomming meeting in 2015 , and the president of the congress would be head of the Iranian Delegate , we are preparing for holding the meeting and organizing the scientific committee of the upcoming congress in tehran, Also there were suggestions for joit activity and multicenter clinical trials
Your experiences about the travel processes(Providing ticket, accommodation,...) : The costs were expensive and the attendee pain their costs on their own
Please give a briefing of your own observations and outcomes of the congress: : The congress was a great success for Islamic Republic of Iran and Tehran Univ. of Med. Sciences. The Iranian Delegate deliberately contributed to the meeting . we had six lectures and 9 abstracts published in the abstract book
It seems that we were able to present a good feature of stem cell research after revolution in Iran 
in various medical fields. The final stakeholders of that would be patients with neurological disabilities.
Especially the pivotal role of islamic replic of iran in future stem cell researches would be a promising issue in the scientific outline of the country

 

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