Parichehr Pasbakhsh | International Congress Form
Application Code :
306-0214-0121
Created Date : Sunday, November 30, 2014 11:07:35Update Date : Sunday, February 22, 2015 10:19:19
IP Address : 194.225.51.101Submit Date : Saturday, February 21, 2015 13:39:15Email : pasbakhsh@hotmail.com
Personal Information
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Name : |
Parichehr |
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Surname : |
Pasbakhsh |
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School/Research center : |
School of Medicine |
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If you choose other, please name your Research center : |
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Possition : |
Professor |
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Tel : |
+98-21-44644585 |
Information of Congress
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Title of the Congress : |
8th asia pacific cervical spine meeting |
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Title of your Abstract : |
17β-Estradiol Enhances the Efficacy of Adipose-Derived Mesenchymal Stem Cells on Remyelination in Mouse Model of Multiple Sclerosis |
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country : |
Turkey |
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From : |
Wednesday, November 12, 2014 |
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To : |
Saturday, November 15, 2014 |
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Abstract(Please copy/paste the abstract send to the congress) : |
Introduction: Previous studies have demonstrated the potential of monotherapy with either mesenchymal stem cells (MSCs) or estrogen in autoimmune and cuprizone models of multiple sclerosis (MS).
The aim of this study was to examine the effects of co-administration
of 17β-estradiol (E2) and adipose-derived mesenchymal stem cells (ADSCs) on remyelination of corpus callosum axons in a cuprizone model of MS.
Method: Forty eight male C57BL/6 mice were fed cuprizone (0.2%) for 6 weeks. At day 0 after cuprizone removal, animals were randomly divided into four groups. The E2 monotherapy, ADSCs monotherapy, E2/ADSCs combined therapy and vehicle control.
Some mice of the same age were fed with their normal diet to serve
as healthy control group. E2 pellets, designed to release 5.0 mg E2
over 10 days, were implanted subcutaneously. 106 PKH26 labeled ADSCs were transplanted into lateral tail. Th extent of demyelination, remyelination, and cell type’s composition of host brain were examined at 10 days post-transplantation in the body of the corpus callosum. Results:Transplanted cells migrated to the corpus callosum injury. Histological examination revealed efficacy of intravenous ADSCs transplantation in remyelination of mouse cuprizone model of MS can be significantly enhanced by E2 administration. Flow cytometry showed that the mean percentages of expression of Iba-1, Olig2 and O4 were significantly increased in E2/ADSCs combined therapy in comparison with ADSCs monotherapy.
Conclusion: the findings of this study revealed that E2 administration enhanced efficacy of intravenous ADSCs transplantation in remyelination of corpus callosum axons in mouse cuprizone model of MS.
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Keywords of your Abstract : |
Keywords: Adipose-derived mesenchymal stem cells; Demyelination; 17β-Estradiol |
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Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/11925/Forms/306/From.docx |
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The presentation : |
Poster |
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The Cover of Abstract book : |
 |
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Published abstract in the abstract book with the related code : |
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Where has your abstract been indexed? : |
ISI |
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If you choose other, please name : |
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The Congress Reporting Form
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How many volunteers were present at the Congress? : |
About 150 volunteers were present at the Congress |
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Delegates from which countries presented in the congress? : |
Korea Thiland India Japan Poland China Greece Egypt... |
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Were the delegates of any other organizations present in the congress? : |
Yes |
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If yes, please write the names of the organizations in the box : |
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What were the responses to your talking points? Were specific questions or concerns raised? : |
Some questions were raised about : the findings of this study and the material and method of my experiance...................... |
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If you met staff members, please list their full names & positions. : |
Mehmet Zileli |
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Please inform us if there are any follow up actions we need to talk with the members of the congress : |
No special thing to mention. The congress was scheduled for 3 days where recent developments in cervical spine ,surgery of cervical spine were reviewed.This congress was very good and benefit for Young scientific , neurological surgeons and for Anatomist participate. Poster presentatiopn were presented 2 minutes . |
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Your experiences about the travel processes(Providing ticket, accommodation,...) : |
The financial suport of Tehran university of medical sciences is not enough for providing ticket ,registration and accomodation... |
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Please give a briefing of your own observations and outcomes of the congress: : |
The main goal of the APCSS meeting was to pave the way for a scientific environment where recent developments in cervical spine were reviewed the results of research were discussed and ideas were exchanged.They also have been discussing the regional and global aspects of social political and economic issues related to spine surgery. Most of the participant were Orthopeic surgeons or Neurosurgen......and their researches were about the new aprroch to cervical spine and to aneurysm and tumors and neurosurgical endoscopy .They had only oral presentation and poster presentation . |