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Code : 9345-351851 Created Date : Monday, October 3, 2016 Visit : 1455

3rd Middle East-Asia Allergy Asthma and Immunology Congress

3rd Middle East-Asia Allergy Asthma and Immunology Congress by Dr. Maryam Mahmoudi

Application Code :

306-0116-0042

Created Date : Monday, December 28, 2015 19:44:21Update Date : Tuesday, April 5, 2016 13:38:07
IP Address : 192.168.73.28Submit Date : Tuesday, April 5, 2016 13:38:15Email : mahmoodi_maryam@yahoo.com

Personal Information

Name :	Maryam
Surname :	Mahmoudi
School/Research center :	School of Nutritional Sciences and Dietetics
If you choose other, please name your Research center :
Position :	Associate professor
Tel :	+98-21-88955698

Information of Congress

Title of the Congress :	3rd Middle East-Asia Allergy Asthma and Immunology Congress
Title of your Abstract :	Vitamin A Decreases Cytotoxicity of Oxidized Low-Density Lipoprotein in Patients with Atherosclerosis.
Destination Country :	United Arab Emirates
From :	Friday, December 11, 2015
To :	Sunday, December 13, 2015
Abstract(Please copy/paste the abstract send to the congress) :	BACKGROUND: Oxidized low-density lipoprotein (ox-LDL) is implicated in initiation and progression of atherosclerosis. Previously, we found that ox-LDL increases vulnerability of peripheral blood mononuclear cells (PBMCs) in atherosclerotic patients compared to controls. Vitamin A induces proliferation of PBMCs. The aim of this study was to determine the effect of vitamin A supplementation on PBMC survival against LDL and different doses of ox-LDL. METHOD: In this double-blind placebo-controlled trial, we recruited 35 atherosclerotic patients and 38 healthy controls and randomly allocated them into placebo and vitamin A groups, which received either placebo or 25,000 IU/day of vitamin A for 3 months. PBMCs were isolated, cultured, and stimulated by 1 µg/mL LDL as well as 1 µg/mL and 50 µg/mL ox-LDL. The stimulation indexes (SIs) of PBMCs were calculated to identify cell viability. Additionally, the circulating ox-LDL levels were measured by ELISA. RESULTS: Viability of PBMCs stimulated by 50 µg/mL ox-LDL significantly increased following vitamin A supplementation in patients (p < 0.01). The levels of circulating ox-LDL were not changed by vitamin A treatment. Ox-LDL levels were strongly and positively correlated to SI of PBMCs stimulated by 1 µg/mL LDL and1 µg/mL ox-LDL in all groups. CONCLUSION: Vitamin A decreases cytotoxicity of high-dose ox-LDL and improves PBMC viability. The protective effect of vitamin A is not mediated by an antioxidative mechanism, but may instead have been due to intracellular protection of the apoptotic machinery or induction of proliferation of the cells. Higher levels of ox-LDL increase PBMC irritability in all participants.
Keywords of your Abstract :	Vitamin A, Atherosclerosis, T helpers, Peripheral blood mononuclear cells, Cytokines, Oxidized LDL, Immunotherapy, Immune response
Acceptance Letter :	http://gsia.tums.ac.ir/images/UserFiles/27959/Forms/306/Acceptance_1.pdf
The presentation :	Poster
The Cover of Abstract book :	http://gsia.tums.ac.ir/images/UserFiles/27959/Forms/306/Cover2.pdf
Published abstract in the abstract book with the related code :	http://gsia.tums.ac.ir/images/UserFiles/27959/Forms/306/abstract1_1.pdf
Where has your abstract been indexed? :	none
If you choose other, please name :

The Congress Reporting Form

How many volunteers were present at the Congress? :	300
Delegates from which countries presented in the congress? :	USA, UK, Turkey, UAE, India
Were the delegates of any other organizations present in the congress? :	No
If yes, please write the names of the organizations in the box :
What were the responses to your talking points? Were specific questions or concerns raised? :	People were interested in the effect of vitamin A supplementation on immune system and toxicity of high dose of oxLDL on PBMCs. Also they asked questions about how vitamin a can reduce this toxicity.
If you met staff members, please list their full names & positions. :	No
Please inform us if there are any follow up actions we need to talk with the members of the congress :	There is no need to talk with the members of the congress. I'm in close contact with everyone who was interested in my studies. I hope we can do some collaborative work in near future. Specially most people were from middle East and it's very important for future collaborations. we can invite them for workshops and also our international congresses.
Your experiences about the travel processes(Providing ticket, accommodation,...) :	There was no problem.
Please give a briefing of your own observations and outcomes of the congress: :	Participating in 3rd Middle East Allergy Asthma and Immunology congress in Abu Dhabi was very interesting because there were scientists from other middle east countries with the same culture and the same facilities in universities and with different ideas and fields of work. It was obvious that the level of studies in Iran are higher than other developing countries and we were really proud of ourselves. I eagerly looking forward for fruitful results of this congress and more collaborative works and projects and also collaborative articles in near future.

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