Code : 9345-351874      Created Date : Tuesday, October 4, 2016   Visit : 2076

IARC 50th Anniversary Scientific Conference: Global cancer, Occurrence, Causes, and Avenues to Prevention

The report IARC 50th Anniversary Scientific Conference: Global cancer, Occurrence, Causes, and Avenues to Prevention by Dr. Abbas Karimi
Application Code :
306-0216-0076
 
Created Date : Tuesday, June 14, 2016-15:00 15:00:08Update Date : Monday, July 18, 2016-11:20 11:20:46
IP Address : 194.225.49.235Submit Date : Monday, July 18, 2016-11:21 11:21:00Email : abbas.karimi.p@gmail.com
Personal Information
Name : Abbas
Surname : Karimi
School/Research center : Autoimmune Bullous Diseases Research Center (ABDRC)
If you choose other, please name your Research center :  
Position : Assistant professor
Tel : +98-21-55155050
Information of Congress
Title of the Congress : IARC 50th Anniversary Scientific Conference: Global cancer, Occurrence, Causes, and Avenues to Prevention
Title of your Abstract : Exposure of hepatocellular carcinoma cells to low-level As2O3 causes an extra toxicity pathway via L1 retrotransposition induction
Destination Country : France
From : Tuesday, June 7, 2016
To : Friday, June 10, 2016
Abstract(Please copy/paste the abstract send to the congress) : Various mechanisms have been proposed for toxicity and carcinogenesis pattern of arsenic, a naturally
occurring metalloid. The extent to which the long interspersed element-1 (LINE-1) retrotransposon, an
ubiquitous retroelement with autonomous mobility, can be influenced upon exposure to low-level
arsenic remains to be elucidated. The aim of this study was to evaluate the possible effect of low-level
As2O3 on L1 retrotransposition alteration in human hepatocellular carcinoma cells (HepG2).
L1 retrotransposition in HepG2 cells was performed by the in vitro retrotransposition assay using an
EGFP-tagged L1RP. Following determination of non-cytotoxic concentrations of arsenic by a MTT assay,
the cells were transfected with pL1RP-EGFP and then exposed to 0.25, 0.50 and 0.75 mM of As2O3. The
amount of EGFP and its copy number in retrotransposed cells were evaluated by FACS and qPCR analysis
in treated vs. control cells, respectively. Significant increase in retrotransposition frequency was found
after 12 days exposure to 0.50 and 0.75 mM of As2O3 by FACS analysis (P < 0.05). Obtained results were
further confirmed by real time PCR, which showed significant induction of retrotransposition in all
mentioned concentrations. Our
findings indicate that low-level long-term As2O3 exposure may pave
activation of L1 retrotransposon.
Keywords of your Abstract : Retrotransposition
As2O3
Cytotoxicity
LINE-1
Human hepatocellular carcinoma cell
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/30862/Forms/306/Acceptance_of_IARC_50th_Anniversary_Conference_-_Abstract_notification.pdf
The presentation : Oral
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/30862/Forms/306/cover_of_abstract_book.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/30862/Forms/306/IARC50-abstract-book.pdf
Where has your abstract been indexed? : ISI
If you choose other, please name :  
The Congress Reporting Form
How many volunteers were present at the Congress? : Over 1000 participants
Delegates from which countries presented in the congress? : Delegates from different countries of Asia including Iran, Turkey, Jordan, Saudi Arabia, Lebanon, China, Japan, India … and also participants form he EU countries (France, UK, Germany, Netherlands, Italy, Spain, Belgium, Norway, …) and delegates from other countries such as USA, Brazil, Venezuela, Argentina, Egypt,… were attended at the conference.
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : Shahid Beheshti University of Medical Sciences, Tabriz University of Medical Sciences, Mashhad University of Medical Sciences.
What were the responses to your talking points? Were specific questions or concerns raised? : My lecture was held in parallel session on “Mechanisms’’. Once my presentation finished some audiences praised my lecture and asked their questions about the endogenous LINE 1 and post modification effects of arsenic of L1 retrotranspositions events. After my lecture, Professor Franco M. Buonaguro from Napoli, Italy suggested me to collaborate about the cancerous effects of arsenic in volcanic area of Italy on Leukemia patients.
If you met staff members, please list their full names & positions. : I had a meeting with Christopher P. Wild, Director of IARC2016 conference, International Agency for Research on Cancer, Lyon, France about how we can collaborate with IARC on skin neoplasms. 
I also met Pro.Franco M. Buonaguro, Director of the Molecular Biology and Viral Oncology Unit at the Natl Cancer Institute “Fond Pascale “ Napoli-Italy and the Editor in Chief of Infectious agents and cancer journal. We talked how we can develop and expand our relationships on arsenic research in volcanic area of Italy that has more incidence of leukemia.
Please inform us if there are any follow up actions we need to talk with the members of the congress : From the feedback I have received both at the meeting and in the subsequent weeks, I believe the conference was an outstanding success. As IARC stated the conference was the largest ever meeting organized by IARC and they are now actively considering how to maintain this important network of cancer scientists involved, in one way or another, with a shared set of research objectives. In this respect, they may communicate with me further in the weeks ahead.
Your experiences about the travel processes(Providing ticket, accommodation,...) : I did not face any difficulty in travel and accommodation in Lyon since I reserved all these in advance.
Please give a briefing of your own observations and outcomes of the congress: : This was scientific conference to celebrate the 50th anniversary of the International Agency for Research on Cancer

The major themes of this landmark conference were structured around the core activities of IARC and cover global cancer occurrence, etiology, and prevention as well as implementation of prevention and early detection. The conference featured keynote lectures from eminent international cancer researchers, as well as smaller themed workshops and symposia for which contributed papers and poster presentations were invited. The programme also included three debates on controversial issues together with “big picture” lectures linking cancer, science, and society.

 

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