Code : 9345-352203      Created Date : Wednesday, December 28, 2016   Visit : 1372

the 2nd World Congress on Controversies in Breast Cancer (CoBrCa)

The report of the 2nd World Congress on Controversies in Breast Cancer (CoBrCa) by Dr. Reza Ahmadkhaniha
Application Code :
306-0216-0105
 
Created Date : Wednesday, August 17, 2016-12:40 12:40:56Update Date : Sunday, October 16, 2016-10:23 10:23:01
IP Address : 194.225.57.40Submit Date : Saturday, October 15, 2016-14:44 14:44:00Email : r-ahmadkhaniha@tums.ac.ir
Personal Information
Name : Reza
Surname : Ahmadkhaniha
School/Research center : School of Public Health
If you choose other, please name your Research center :  
Position : Assistant professor
Tel : +98-21-88955887
Information of Congress
Title of the Congress : the 2nd World Congress on Controversies in Breast Cancer (CoBrCa)
Title of your Abstract : ANTIPROLIFERATIVE EFFECTS OF ANTHEMIS NOBILIS FRACTION ON HUMAN BREAST CANCER CELLS
Destination Country : Spain
From : Wednesday, September 7, 2016
To : Monday, September 12, 2016
Abstract(Please copy/paste the abstract send to the congress) : Problem Statement: The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors. Breast cancer is considered to be the most familiar malignant tumor in females in western countries; and is becoming more and more widespread in Asia.
Standard cancer therapy generally combines surgery, multi-therapeutic agents and ionizing radiation. The anticancer agents induce cell cycle arrest and/or cell death by apoptotic or non-apoptotic mechanisms including necrosis. Due to the less toxicity and cost effectiveness, traditional herbal medicine increasingly attracts more attentions as alternative cancer
therapies. Chamomile has been used for centuries as a medicinal plant for its anti-inflammatory, analgesic, anti-microbial, anti-spasmic and sedative properties. As a member of compositae family, it is widely represented by two known varieties viz. German chamomile (Matricaria chamomilla) and Roman chamomile (Chamaemelum nobile). Previous studies
exhibited anticancer properties for German chamomile. Chamomile is also known to contain several classes of biologically active compounds including flavonoids and terpenoids.The present study was carried out to investigate the anticancer activity of effective C. nobile extract on Breast cancer cells.
Methods: The cells were treated with varying concentrations (0.001- 0.25 mg/mL) of the extract for 24, 48 and 72 h. Apoptosis induced in MCF-7 cells was measured using annexin V/PI, flowcytometry and western blotting analysis Results: The results showed that C. nobile extract revealed relatively high antiproliferative activity on MCF-7 cells; however, it caused minimal growth inhibitory response in normal cells. The involvement of apoptosis was confirmed by
annexin-V/ PI assay and change in Bax/Bcl-2 ratio. Furthermore, decreased proliferation of MCF-7 cells in the presence of the extract was associated with G2/M phase cell cycle arrest.
Conclusion: These findings confirm that C.nobile extract may contain a diversity of phytochemicals which suppress the proliferation of MCF-7 cells by inducing apoptosis.
Keywords of your Abstract : Chamaemelum nobile; Apoptosis; Cancer; Proliferation
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/32134/Forms/306/Reza acceptance letter_1.pdf
The presentation : Poster
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/32134/Forms/306/cover of abstract book_2.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/32134/Forms/306/R abstract with code_1.pdf
Where has your abstract been indexed? : ISI
If you choose other, please name :  
The Congress Reporting Form
How many volunteers were present at the Congress? : about 1000
Delegates from which countries presented in the congress? : USA, France, Germany, England, Spain, Italy, India, Australia, Canada, Japan, Korea
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : FDA, NIH, WHO, USP
What were the responses to your talking points? Were specific questions or concerns raised? : There are a considerable amount of interest toward application of natural product for therapeutic purpose specially in the case of cancer. Most of the questions were in the field of phytochemistry and the potential application of other plants for cancer therapy.
If you met staff members, please list their full names & positions. : 1- Prof. Bruce Mann, Professor of Surgery at the University of Melbourne and Director of The Breast Service at the Royal Melbourne and Royal Women’s Hospital in Melbourne. He is on the council of Breast SurgANZ, the Scientific Advisory Committee of the ANZ Breast Cancer Trials Group and is past president of the Clinical Oncology Society of Australia. He has been involved in many clinical trials and much clinical and translational research regarding breast cancer, with his main research interest being tailoring treatment to the disease and the patient.
2- Prof. Alastair Thompson, Active in translational laboratory research, he built a breast cancer research program over 15 years in Dundee, including a xenograft program and tissue banking facility with a focus on the p53 network and drug development. He has successfully supervised 20 PhD or research MD students and currently has 4 students completing PhDs. The impact of over 200 peer reviewed research papers has included global firsts demonstrating the effect of drugs in vivo in animal models and in human cancers.
He continues to provide leadership in trials and clinical translational research with colleagues in Europe and Australasia while establishing clinical trials and laboratory collaborations in the US, through membership of the American Society of Clinical Oncology, American Association of Cancer Research, South West Oncology Group and Translational Breast Cancer Research Consortium.
Please inform us if there are any follow up actions we need to talk with the members of the congress : No more action is required. No more action is required.No more action is required. No more action is required.No more action is required. No more action is required. No more action is required. No more action is required.No more action is required. No more action is required No more action is required.No more action is required. No more action is required No more action is required.No more action is required. No more action is required
Your experiences about the travel processes(Providing ticket, accommodation,...) : 1)high cost of life in Barcelona including accommodation, taxi, foods
2)The registration fee was expensive according to Euro conversion rate with Rial
Please give a briefing of your own observations and outcomes of the congress: : There were educational panel, refreshment courses and workshop. At the same time 6 hall were active, and the arrangement was so great, all of the presentation were on time. the commercial sections was full of new technologies, and procedures ready to replace with old and traditional protocols. The new anticancer agents with lower side effects were another interesting point of the exhibition section. The congress was well-organized and every things were held on time. After doing registration and paying registration fee participants could take part in every panels without any extra charge but workshops.
The other point was enthusiastic between participants to take part in the panels. Almost 10 minutes before each panel all the sits were occupied and there were no more free sits so, many persons while sitting on the floor were following the presentations.

 

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