Code : 9345-352204      Created Date : Wednesday, December 28, 2016   Visit : 1699

the 2nd World Congress on Controversies in Breast Cancer (CoBrCa)

The report of the 2nd World Congress on Controversies in Breast Cancer (CoBrCa) by Dr. Noushin Rastkari
Application Code :
306-0216-0117
 
Created Date : Saturday, October 15, 2016-15:20 15:20:25Update Date : Sunday, October 16, 2016-12:58 12:58:47
IP Address : 194.225.57.40Submit Date : Sunday, October 16, 2016-13:00 13:00:44Email : n_rastkari@yahoo.com
Personal Information
Name : Noushin
Surname : Rastkari
School/Research center : Institute for Environmental Research (IER)
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Position : Associate professor
Tel : +98-21-88978395
Information of Congress
Title of the Congress : the 2nd World Congress on Controversies in Breast Cancer (CoBrCa)
Title of your Abstract : RELATIONSHIP BETWEEN URINARY BISPHENOL A LEVELS AND BREAST CANCER
Destination Country : Spain
From : Wednesday, September 7, 2016
To : Monday, September 12, 2016
Abstract(Please copy/paste the abstract send to the congress) : Problem Statement: Breast cancer is the most frequent cancer and the most common cause of death from cancer among women worldwide. Endocrine-disrupting chemicals (EDCs) have been suspected as potential risks of increasing cancers in reproductive systems and mammary gland, such as prostate cancer, breast cancer, etc. The estrogen-mimic bisphenol A (BPA) is a synthetic phenolic compound which people are exposed to frequently via different exposure routes. BPA acts as an estrogen mimetic, and can interact with the ligand binding domain of ERα, increasing cellular
proliferation, potentially via reducing the rate of apoptosis, and inducing a gene expression profile that clusters with breast cancer poor prognosis. Studies suggest that environmental exposure to BPA is associated with behavioral and reproductive abnormalities, as well as chronic diseases. These findings raise important questions regarding the potential impacts of BPA on breast tissue and because animal studies found that BPA contributes to development of breast cancer, but human data are scarce we hypothesized that urinary levels of BPA may be positively associated with inducing neoplastic processes in the breast.
Methods: In this case-control s study, we compared urinary BPA levels in patients with malignant breast mass (N=15), benign breast mass (N=15) and, women with normal breast (N=15). All the case and control participants supplied urine samples that were then analyzed for total BPA concentration. BPA was analyzed using solid-phase extraction coupled
with gas chromatography-mass spectrometry after derivatization with BSTFA. Urinary BPA was compared among the three target groups of study using Kruskal-Wallis nonparametric test. Continuous variables are presented as mean (95% confidence interval), and categorical variables are shown as proportions (percentages). Association between urinary BPA with benign and malignant breast masses was tested using multinomial logistic regression models (unadjusted and adjusted for potential confounding variables models).
Results: Mean age of the 45 participants was 44.3±11.5 years, with a range of 19 to 71 years. Concentration of BPA had significant differences among target groups (P<0.05). Pairwise comparisons displayed a significant difference between malignant and control group. When we compared BPA levels among patients with benign or malignant mass and control, the median value of BPA levels was higher in the patients with breast masses than the ontrol(malignant mass> benign mass > control). In the multinomial logistic regression models, we observed a positive association (P<0.05) between
increasing urinary BPA levels with both malignant and benign breast mass in unadjusted and the multivariable-adjusted models (for age, age of menarche, breastfeeding duration, use of OCP during the last 5 years and eating perheated canned food during the last year).
Conclusion: Our results have shown a strong positive association between urinary concentrations of BPA and both benign and malignant breast masses, but future independent replication and follow up studies are needed to confirm or disprove these findings. If the results of this research would be confirmed in future prospective studies, reducing BPA
exposure may play a role in the prevention and reduce of breast cancer incidence.
Keywords of your Abstract : bisphenol A, Breast cancer, exposure
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/33781/Forms/306/N_acceptance_letter.pdf
The presentation : Poster
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/33781/Forms/306/cover_of_abstract_book.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/33781/Forms/306/N_abstract_with_code.pdf
Where has your abstract been indexed? : ISI
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The Congress Reporting Form
How many volunteers were present at the Congress? : about 1000
Delegates from which countries presented in the congress? : USA, France, Germany, England, Spain, Italy, India, Australia, Canada, Japan, Korea
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : FDA, NIH, WHO, USP
What were the responses to your talking points? Were specific questions or concerns raised? : There are a considerable amount of interest toward application of natural product for therapeutic purpose specially in the case of cancer. Most of the questions were in the field of phytochemistry and the potential application of other plants for cancer therapy.
If you met staff members, please list their full names & positions. : Prof. Bruce Mann, Professor of Surgery at the University of Melbourne and Director of The Breast Service at the Royal Melbourne and Royal Women’s Hospital in Melbourne. He is on the council of Breast SurgANZ, the Scientific Advisory Committee of the ANZ Breast Cancer Trials Group and is past president of the Clinical Oncology Society of Australia. He has been involved in many clinical trials and much clinical and translational research regarding breast cancer, with his main research interest being tailoring treatment to the disease and the patient.
2- Prof. Alastair Thompson, Active in translational laboratory research, he built a breast cancer research program over 15 years in Dundee, including a xenograft program and tissue banking facility with a focus on the p53 network and drug development. He has successfully supervised 20 PhD or research MD students and currently has 4 students completing PhDs. The impact of over 200 peer reviewed research papers has included global firsts demonstrating the effect of drugs in vivo in animal models and in human cancers.
He continues to provide leadership in trials and clinical translational research with colleagues in Europe and Australasia while establishing clinical trials and laboratory collaborations in the US, through membership of the American Society of Clinical Oncology, American Association of Cancer Research, South West Oncology Group and Translational Breast Cancer Research Consortium.
Please inform us if there are any follow up actions we need to talk with the members of the congress : No more action is required. No more action is required.No more action is required. No more action is required.No more action is required. No more action is required. No more action is required. No more action is required.No more action is required. No more action is required No more action is required.No more action is required. No more action is required No more action is required.No more action is required. No more action is required.
Your experiences about the travel processes(Providing ticket, accommodation,...) : 1) high cost of life in Barcelona including accommodation, taxi, foods
2) The registration fee was expensive according to Euro conversion rate with Rial
Please give a briefing of your own observations and outcomes of the congress: : There were educational panel, refreshment courses and workshop. At the same time 6 hall were active, and the arrangement was so great, all of the presentation were on time. the commercial sections was full of new technologies, and procedures ready to replace with old and traditional protocols. The new anticancer agents with lower side effects were another interesting point of the exhibition section. The congress was well-organized and every things were held on time. After doing registration and paying registration fee participants could take part in every panels without any extra charge but workshops.
The other point was enthusiastic between participants to take part in the panels. Almost 10 minutes before each panel all the sits were occupied and there were no more free sits so, many persons while sitting on the floor were following the presentations.

 

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