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Title of the Congress : |
THE 24TH WORLD CONGRESS ON CONTROVERSIES IN OBSTETRICS, GYNECOLOGY & INFERTILITY (COGI) |
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Title of your Abstract : |
THE EFFECTS OF MALE HYPERINSULINEMIA ON IVF OUTCOMES |
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Destination Country : |
Netherlands |
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From : |
Thursday, November 10, 2016 |
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To : |
Sunday, November 13, 2016 |
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Abstract(Please copy/paste the abstract send to the congress) : |
ABSTRACT
Background: Combination of sedentary life and high fat/carbohydrate containing diets predisposes a person to elevated serum insulin level and insulin resistance. Raising serum insulin level has been recently suggested to inversely influence on normal spermatogenesis by altering in androgenic hormones profile. Hyperinsulinemia can also contribute to impaired sperm function by increasing in inflammatory chemicals, free radicals, and reactive oxygen species (ROS) production. Higher percentage of poorly compacted sperm deoxyribonucleic acid (DNA) was detected in hyperinsulinemic men. These research evidences prompted us to evaluate the influence of male hyperinsulinemia on in vitro fertilization (IVF) outcomes.
Methods & Materials: A case-control study was performed on 114 infertile couples who were candidate for IVF program at a university –affiliated IVF Unit, in 2015. The precipitating males were the healthy and normozoospermic men. The participating women were younger than 36 years old with tubal factor as infertility cause and having more than three oocytes in a conventional stimulation programs. The subjects were divided in two groups according to male partner insulin levels; the patients with serum insulin level ≤ 9 µIU/ml as the control group (n = 93) and the patients with serum insulin levels > 9 µIU/ml as the case group (n = 21). The main outcome measures were semen parameters, fertilization rate, number of embryos, embryo quality, biochemical pregnancy rate, and clinical pregnancy rate.
Results: There was no statistically significant difference between the groups regarding the demographic data. Two groups did not differ statistically in terms of sperm parameter values including; sperm concentration, motility and morphology (ρ= 0. 41, ρ= 0. 38, ρ= 0. 22, respectively). The fertilization rate of the group with normal serum insulin levels was statistically higher than that of the hyprinsulinemic group (72.12% vs. 43.61%, ρ= 0.041). There was a slight linear association between serum insulin levels and number of embryos (r = 0.209, ρ= 0.038). The hyperinsulinemic men had lower embryo quality than control group (ρ= 0. 013).Nevertheless, no association were found between serum insulin levels and biochemical pregnancy rates (35.41% vs. 37.23%) and clinical pregnancy rates (26.34% vs. 29.58%) in the case and control groups (ρ= 0.453 , ρ=0.764 , respectively).
Conclusion: Male insulin levels may influence embryo quality and fertilization rates in an IVF program. In fact, these findings call for greater clinical awareness of adverse effects of male hyperinsulinemia on male reproductive health. |
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Keywords of your Abstract : |
Hyperinsulinemia, Male factor infertility, Intracytoplasmic sperm injection, ICSI, |
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Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/21571/Forms/306/acceptance_2.pdf |
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The presentation : |
Oral |
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The Cover of Abstract book : |
http://gsia.tums.ac.ir/images/UserFiles/21571/Forms/306/cover_3.pdf |
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Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/21571/Forms/306/publish_2.pdf |
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Where has your abstract been indexed? : |
none |
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If you choose other, please name : |
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