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Title of the Congress : |
12th European Congress on Epileptology 2016 |
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Title of your Abstract : |
1) Investigation the convulsive effect of levosimendan in PTZ-induced seizure threshold in mice: possible involvement of KATP/NO
2) Licofelone, a COX/5-LOX inhibitor, prevented status epilepticus induced by lithium-pilocarpine through iNOS decrement in wistar rats |
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Destination Country : |
Czech Republic |
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From : |
Sunday, September 11, 2016 |
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To : |
Friday, September 16, 2016 |
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Abstract(Please copy/paste the abstract send to the congress) : |
Finding novel anti-seizure drugs can be an appropriate choice in the field of epilepsy control as a candidate for treatment of epilepsy or as an adjunctive therapy alongside other anti-epileptic drugs. There are several reports suggesting the potential anticonvulsant effects of levosimendan; exerting neuroprotective effects and decreasing mortality in some conditions in which seizures can be a cause of death. However, the underlying mechanism responsible for neuroprotective effects of levosimendan is not fully understood. Based on the evidence suggesting levosimendan to be a KATP channel opener and nitrergic pathway activator, levosimendan may alter seizure susceptibility through KATP channels and nitrergic pathway. In this study, the effect of levosimendan was investigated on PTZ-induced seizure in mice. Injection of a single effective dose of levosimendan significantly reduces the susceptibility to PTZ-induced seizure and increases the nitrite level in the hippocampus and temporal cortex. Pretreatment with noneffective dose of a KATP channel blocker [glibenclamide] and a non-selective NOS inhibitor [L-NAME] prevented the anticonvulsant and nitrite elevating effects of levosimendan. While a neural NOS inhibitor [7-NI] prevented the anticonvulsant effect of levosimendan, an inducible NOS inhibitor [aminoguanidine] failed to prevent the anticonvulsant effects of levosimendan. A KATP channel opener [cromakalim] or an NO precursor [L-Arginine] augmented the anticonvulsant effects of a subeffective dose of levosimendan. In addition, co-administration of noneffective doses of glibenclamide and L-NAME demonstrated a synergistic effect in blocking the anticonvulsant effects of levosimendan. Levosimendan exerts anticonvulsant properties probably through activation of KATP/nNOS/NO pathway in the hippocampus and temporal cortex. |
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Keywords of your Abstract : |
levosimendan; seizure; mice |
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Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/7968/Forms/306/acceptance.pdf |
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The presentation : |
Poster |
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The Cover of Abstract book : |
http://gsia.tums.ac.ir/images/UserFiles/7968/Forms/306/cover.pdf |
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Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/7968/Forms/306/poster_1.pdf |
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Where has your abstract been indexed? : |
ISI |
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If you choose other, please name : |
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