Code : 9345-352363      Created Date : Saturday, February 4, 2017   Visit : 1609

43rd Controlled Release Society Annual Meeting & Exposition

The report of 43rd Controlled Release Society Annual Meeting & Exposition by Dr. Farid Dorkoosh
Application Code :
306-0216-0125
 
Created Date : Tuesday, November 1, 2016-08:27 08:27:00Update Date : Wednesday, November 9, 2016-09:21 09:21:30
IP Address : 192.168.123.49Submit Date : Wednesday, November 9, 2016-09:21 09:21:41Email : dorkoosh@tums.ac.ir
Personal Information
Name : Farid
Surname : Dorkoosh
School/Research center : School of Pharmacy
If you choose other, please name your Research center :  
Position : Associate professor
Tel : +98-21-88009440
Information of Congress
Title of the Congress : 43rd Controlled Release Society Annual Meeting & Exposition
Title of your Abstract : Aripiprazole loaded in situ forming implant; an innovative alternative for treatment of schizophrenia
Destination Country : United States
From : Sunday, July 17, 2016
To : Wednesday, July 20, 2016
Abstract(Please copy/paste the abstract send to the congress) : Purpose: Multiple applications of antipsychotic agents are the main obstacle upon treatment of schizophrenia. Due to behavioral abnormalities, low compliance is observed in the most of psychotic patients. In situ forming implants (ISFI) are a suitable choice for delivery of antipsychotic agents due to its easy administration process and sustained release kinetics [1, 2]. In this study, a novel poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) based in situ implant system was developed for aripiprazole (APZ); an atypical antipsychotic agent [3].
Methods: The aim of this study was to develop an in situ forming implant for delivery of APZ. The solubility of APZ was assessed. Using D-optimal design, important experimental parameters such APZ feed and PHBV feed were analyzed. Afterwards, polymer-drug interactions were studied by Forier transform infrared spectroscopy (FTIR). Scanning electron microscopy revealed morphological characteristics of developed ISFI system. Rheological aspects of implants such as viscosity were assessed. In vitro release studies clarified release pattern of APZ in the developed system.
Results: Experimental design modeling demonstrated that increasing initial APZ feed lead to an increase of Entrapment Efficiency (ER%) and Drug Loading (DL%). ER% and DL% were optimized at 99.32% and 75.23%, respectively. Rheological analyses demonstrated that the developed formulation is highly cross-linked gel with possible capability for controlled delivery of APZ. According to FTIR studies, APZ was intact within polymer networks. Release studies demonstrated a biphasic pattern of release. After initial burst release, a sustained pattern was observed for the next 18 days. The initial burst release was decreased by increasing initial polymer feed. According to SEM analysis, porosity of PHBV network is increased significantly compared to first day of release study. SEM morphological studies authenticated the hypothesis that APZ is mainly released by gradual disintegration of PHBV networks, in second phase of release test. The release data fitted to Korsmeyer-Peppas model and release pattern found out to be non-fickian.
Figure 1. In vitro release profile of APZ in PBS (pH =7.4) medium. Fig 2. SEM image of APZ loaded implant (a) first day (b) 18th day of release analysis.
Conclusions: APZ loaded implants seems to be an innovative alternative instead of common treatments of schizophrenia due to its optimal physicochemical characteristics.
Acknowledgements: This study was founded and supported by Tehran University of Medical Sciences (TUMS), grant number 93-02-33-26190.
References:
1. Wang, L., et al.. International journal of pharmaceutics. 2012.
2. Kempe, S. and K. Mäder.. Journal of Controlled Release. 2012.
3. Shapiro, D.A., et al. Neuropsychopharmacology. 2003.
Keywords of your Abstract : Aripiprazole, Implant, Schizophrenia
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/11270/Forms/306/Acceptance letter_2.pdf
The presentation : Poster
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/11270/Forms/306/2016_Program_Book_2.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/11270/Forms/306/Abstract 241_2.pdf
Where has your abstract been indexed? : none
If you choose other, please name :  
The Congress Reporting Form
How many volunteers were present at the Congress? : 800
Delegates from which countries presented in the congress? : From many countries including USA, UK, Germany, France, Italy, Spain, the Netherlands, Belgium, China, Japan, Iran, Turkey, Egypt, etc.
Were the delegates of any other organizations present in the congress? : No
If yes, please write the names of the organizations in the box :  
What were the responses to your talking points? Were specific questions or concerns raised? : I had poster presentation and there were some questions regarding how this implant can be manufactured and how can be applied to patients.
If you met staff members, please list their full names & positions. : Many professors such as Wim Hennink, Sevda, Senel, Kinam Park, Sandy Florance, Hans Junginger
Please inform us if there are any follow up actions we need to talk with the members of the congress : No needed for any further follow up however this is good if you can promote this conference in Iran for the people in the field of Pharmaceutics to take part more in such a conferences from Iran..................................................................................................................
Your experiences about the travel processes(Providing ticket, accommodation,...) : It was a good conference that I take part annually.
Please give a briefing of your own observations and outcomes of the congress: : This CRS conference is very useful for our staff at department of pharmaceutics as many new topics such a co-delivery of medicines, gene delivery, delivery of macromolecules, drug targeting, etc were presented. We can learn a lot by taking part in this conference about new developments on research activities towards new formulations. Moreover, it is also esstential to understand that taking part in a conference is not only important for your own knowledge about the new developments in your field but also one can establish great contacts for future collaborations. Therefore, this is highly recommended to all our faculty members to get involved and take part in such an important internation conferences

 

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