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Title of the Congress : |
27th EUROPEAN STUDENTS` CONFERENCE |
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Title of your Abstract : |
Comparing the Bleeding and Complications of Total Knee Arthroplasty After Topical and Intravenous Tranexamic Acid Injection: A Randomized Clinical Trial |
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Destination Country : |
Germany |
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From : |
Wednesday, September 28, 2016 |
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To : |
Saturday, October 1, 2016 |
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Abstract(Please copy/paste the abstract send to the congress) : |
TITLE: COMPARING THE BLEEDING AND COMPLICATIONS OF TOTAL KNEE
ARTHROPLASTY AFTER TOPICAL AND INTRAVENOUS TRANEXAMIC ACID INJECTION:
A RANDOMIZED CLINICAL TRIAL
INTRODUCTION: Total knee arthroplasty has much blood loss. One way for reducing this amount
of blood loss is prescribing anti fibrinolytic drugs such as Tranexamic acid with different doses
and topical and intravenous injection. There is no approved superiority between topical and
intravenous Tranexamic acid injection after total knee arthroplasty. This study was designed to
compare the complications of total knee arthroplasty after injection of topical and intravenous
Tranexamic acid.
METHODS: In this randomized clinical trial, patients referred to Baqiyatallah Orthopedic clinic in
May 2015 to May 2016 for total knee arthroplasty were included. Those who had any history of
renal, cardiovascular, cerebrovascular and thromboembolic disorders were excluded. Informed
consent was obtained from patients. Patients were divided randomly into two groups by random
numbers table; group one received 20mg/kg intravenous Tranexamic acid (10mg/kg before and
after operation) while group two received 1.5gr topical Tranexamic acid. The bleeding amount,
before and after operation hemoglobin, need for blood transfusion, mean surgery time, mean ad
mission time and other complication were compared between the two groups by SPSS software.
RESULTS: Fifty-six patients with the mean age of 60.13 ± 5.74 years were evaluated. No sig
nificant differences were observed in demographic data such as age, gender, weight and BMI
between two groups. There were no significant differences in hemoglobin levels before (P va
lue=0.424 ) and after surgery ( P value=0.110), operation and post-op bleeding (P Value= 0.157),
need for blood transfusion (P Value=0.313), hematoma, mean surgery time (P Value=0.521),
mean admission time (P Value=0.373) and total complications (P Value=0.533), between the
groups. Only one patient in the intravenous group needed blood transfusion. None of patients
had DVT and pulmonary embolism.
CONCLUSION: Considering that no significant differences was seen between topical and intra
venous Tranexamic acid, topical use is recommended in patients having problem with systemic
Tranexamic acid. However, because of different results, heterogeneous samples, and confound
ing factors of previous studies, approving above results need more evaluations. |
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Keywords of your Abstract : |
Total knee arthroplasty, Bleeding, Tranexamic acid, Complications |
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Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/34465/Forms/306/acceptance.pdf |
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The presentation : |
Poster |
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The Cover of Abstract book : |
http://gsia.tums.ac.ir/images/UserFiles/34465/Forms/306/cover.pdf |
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Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/34465/Forms/306/Abs.pdf |
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Where has your abstract been indexed? : |
none |
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If you choose other, please name : |
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