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Title of the Congress : |
10th International Conference on Neuroscience and Neurochemistry 2017. |
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Title of your Abstract : |
Evaluation of chronic losartan treatment effect on
cardiac chronotropic dysfunction in biliary cirrhotic rats. |
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Destination Country : |
Netherlands |
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From : |
Monday, February 27, 2017 |
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To : |
Tuesday, February 28, 2017 |
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Abstract(Please copy/paste the abstract send to the congress) : |
Cirrhosis is associated with cardiac chronotropic and
inotropic dysfunction which is known as cirrhotic
cardiomyopathy. Cardiac responsiveness to
adrenergic stimulation is impaired in cirrhosis.
Moreover there is vagal nerve dysfunction which is
related to neuromodulatory dysfunction of the
angiotensin II in the cirrhosis. This study was aimed
to explore the hypothesis that administration of
Losartan-angiotensin II receptor antagonistincreases
cadiac chronotropic response to
isoproterenol in cirrhotic rats; and if so, whether this
is associated with altered cardiac TGF-β receptor
expression. Cirrhosis was induced by surgical ligation
of the bile duct (BDL) in male Wister rats. Half of the
BDL-group and control group were treated with
losartan for four weeks. Four weeks after bile duct
ligation or sham surgery the atria were isolated and
spontaneously beating rate and chronotropic
responsiveness to β-adrenergic stimulation was
assessed using standard organ bath. Pathological
assessment was done on the atria. Moreover the
expression of TGF-β was assessed the atria using
quantitative RT-PCR. Bile duct ligation could induce a
significant hypo-responsiveness to adrenergic
stimulation. In cirrhotic rats, the chronotropic
responses increased after chronic treatment with
losartan but it was not significant. Pathological study
showed that losartan decreases fibrosis in atria in
losartan treated cirrhotic group. TGF-β expression is
markedly increased in cirrhotic rats which is
significantly decreased in atria following
administration of losartan. These results might be
considered as angiotensin II role in cirrhotic
cardiomyopathy but further studies are required to
elaborate the mechanism as well as possible
advantage of losartan. We conclude that cirrhosis in
rats is associated with altered expression of TGF-β in
atrium which losartan can ameliorate it. |
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Keywords of your Abstract : |
cirrhosis-cardiomyopathy-losartan |
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Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/24724/Forms/306/invitation_1.pdf |
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The presentation : |
Oral |
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The Cover of Abstract book : |
http://gsia.tums.ac.ir/images/UserFiles/24724/Forms/306/cover_2.pdf |
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Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/24724/Forms/306/abstract.con_1.pdf |
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Where has your abstract been indexed? : |
other |
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If you choose other, please name : |
Chemical Abstracts Service (CAS) Index Copernicus Google Scholar |