marzieh salimi | International Congress Form
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Application Code :
762-0217-0029
Created Date : Monday, July 10, 2017-00:49 00:49:48Update Date : Thursday, July 13, 2017-01:16 01:16:24
IP Address : 194.225.61.122Submit Date : Thursday, July 13, 2017-01:16 01:16:40Email : m_salimi_rt@yahoo.com
Personal Information
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Name : |
marzieh |
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Surname : |
salimi |
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School/Research center : |
School of Medicine |
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If you choose other, please name your Research center : |
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Position : |
student |
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Tel : |
+98-913-3885003 |
Information of Congress
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Title of the Congress : |
34th Annual Society for Thermal Medicine Meeting |
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Title of your Abstract : |
Magnetic hyperthermia and MR imaging using G4 PAMAM dendrimer coated Fe3O4 nanoparticles |
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Destination Country : |
Mexico |
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From : |
Saturday, April 29, 2017 |
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To : |
Tuesday, May 2, 2017 |
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Abstract(Please copy/paste the abstract send to the congress) : |
Introduction:
Recently, hyperthermia has been increasingly applied in the cancer treatment since it has favourable advantages compared with other treatments including chemotherapy and radiotherapy. Iron oxide magnetic nanoparticles are used in magnetic bioseperation, clinical diagnosis and therapy including MRI and magnetic hyperthermia thanks to their very low toxicity and good biocompatibility. The polyamidoamine (PAMAM) dendrimer coated iron oxide magnetic nanoparticles(MNPs) have internal cavities makes them suitable for application in multidisciplinary cancer treatments. In this study, we assessed efficiency of G4 PAMAM coated Fe3O4 NPs(PAMAM@Fe3O4) in magnetic hyperthermia and MR imaging.
Method and materials:
Fe3O4 MNPs were synthesized by coprecipitation of Fe3+ and Fe2+ solution followed by surface modification with PAMAM dendrimers. The morphology and properties of obtained nanoparticles were characterized by XRD, FT-IR, TEM and DLS. The PAMAM@Fe3O4 NPs displayed relatively high magneto-temperature response which could be applied to hyperthermia therapy. In vivo and in vitro toxicity was assessed as well as hemolysis. The relaxivity values (r1, r2) were estimated using a linear fit to R1 and R2 versus nanoparticles concentration curves, respectively.
Results
The size of nanoparticles was approximately 10nm and the result of DLS shown 108nm hydrodynamic size. The temperature rising of NP samples measured in two frequencies of 200 and 300kHz and intensity of 12kA/m. The introduced SAR increased by increasing frequency and NPs concentration and the outcomes revealed that these MNPs could be promising materials for local hyperthermia. The toxicity of PAMAM@Fe3O4 NPs was negligible, the renal and hepatic factors in blood as well as blood proteins did not change significantly in selected NPs concentrations used in chronic and acute toxicity in bulb-c mice. The highest amount of Hemolysis was only 8% in at NPs concentration of 1 mg/ml. Longitudinal and transverse relativities were 4.17 s-1mM-1 and 139.12 s-1mM-1, respectively.
Discussion
There are some studies focused on PAMAM@Fe3O4 NPs as an MRI contrast agent or a vehicle for drug delivery. Considering to suitable magnetization properties of these NPs, we decided to investigate them in magnetic hyperthermia. For clinical use, NPs must be toxic as low as possible. Our results shown that PAMAM@Fe3O4 NPs were very low toxic in cancer and normal cell lines and this is due to dendrimer coating of NPs and PEGylation. Because of dendrimers superior properties in MRI and drug delivery, they can be suitable candidate to consider as an appropriate coating for magnetite NPs using in magnetic hyperthermia.
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Keywords of your Abstract : |
Magnetic hyperthermia, Dendrimer-coated iron oxide, MRI, breast cancer |
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Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/36321/Forms/762/STM 2017 Letter of Invitation M_Salimi_1.pdf |
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The presentation : |
Oral |
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The Cover of Abstract book : |
http://gsia.tums.ac.ir/images/UserFiles/36321/Forms/762/cover_1.pdf |
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Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/36321/Forms/762/paper in book_1.pdf |
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Where has your abstract been indexed? : |
ISI |
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If you choose other, please name : |
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The Congress Reporting Form
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How many volunteers were present at the Congress? : |
more than 70 |
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Delegates from which countries presented in the congress? : |
USA ,Germany, The Netherlands, Europe |
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Were the delegates of any other organizations present in the congress? : |
No |
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If yes, please write the names of the organizations in the box : |
- |
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What were the responses to your talking points? Were specific questions or concerns raised? : |
the methodes of my work and the matterials |
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If you met staff members, please list their full names & positions. : |
Prof. Robert Ivkov from John Hopkins university |
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Please inform us if there are any follow up actions we need to talk with the members of the congress : |
no |
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Your experiences about the travel processes(Providing ticket, accommodation,...) : |
I bougth the ticket from KLM and airomexico corporations and about my hotel I accomodated in a student hotel at Cancun. |
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Please give a briefing of your own observations and outcomes of the congress: : |
This congress was an outstanding meeting in hyperthermia treatment including many aspects of hyperthermia such as biology, physics and clinical use, which many scientists from developed contries took part in that.
I became familliar with the novel works in my dessertaion field (magnetic hyperthermia) in other contries and could get some unique ideas from the scientific talks |