Behnaz Esmaeili | International Congress Form
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Application Code :
762-0217-0031
Created Date : Sunday, July 16, 2017-12:28 12:28:44Update Date : Monday, August 28, 2017-09:14 09:14:33
IP Address : 188.245.44.40Submit Date : Sunday, August 27, 2017-17:49 17:49:07Email : esmaeili.behnaz@yahoo.com
Personal Information
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Name : |
Behnaze |
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Surname : |
Esmaeili |
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School/Research center : |
School of Medicine |
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If you choose other, please name your Research center : |
Immunology |
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Position : |
student |
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Tel : |
+98-21-66419536 |
Information of Congress
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Title of the Congress : |
EAACI 2017 |
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Title of your Abstract : |
Investigation of IL-17 producing CD26-/low memory Treg cells in patients with psoriasis |
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Destination Country : |
Finland |
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From : |
Saturday, June 17, 2017 |
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To : |
Wednesday, June 21, 2017 |
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Abstract(Please copy/paste the abstract send to the congress) : |
Introduction
Defects in frequency and function of regulatory T cells (Treg) have been shown in Psoriasis. Under ex vivo stimulation, IL-17+ Treg cells were significantly increased in psoriasis patients compared to normal subjects. CD26, a surface molecule with dipeptidyl peptidase activity, is expressed mainly on effector T cells which is negative or low on Treg cells. We aimed to evaluate IL-17+ CD26-/low memory Treg cells in patients with psoriasis.
Method
In this study, we isolated memory T cells from 10 patients and 10 sex and age matched controls. The cells were activated with anti CD3/CD28 for 48h and stimulated with PMA/ionomycin for 4.5h. IL-17+ Foxp3+CD25+ CD26-/low and CD26hi subpopulations in memory T cells were evaluated. The samples were acquired on flow cytometry and data were analyzed by FlowJo 7.6.
Result:
Our results revealed that the percentage of IL-17 producing Foxp3+CD25+CD26-/low memory T cells, which were considered as regulatory cells, decreased in patients compared to controls. (Mean ± SEM; 32.4 ± 5.2, 39.1± 4.6, respectively), although it was not statistically significant, (P=0.35). Investigation of intracellular IL-17 producing Foxp3+CD25+CD26hi memory T cells, which were considered as effector cells) indicated not significantly reduced in percentage of IL-17 producing cells from patients compared to controls.(Mean ± SEM; 53.2 ± 3.6, 64.7± 4.2, respectively, P=0.062).(Figure 2)
Conclusion:
Taken together, our results were in contrast with previous evidences regarding to IL-17 production in ex vivo stimulated Treg cells in patients with psoriasis. Present finding propose that the major of IL-17 producing cells (both in CD26 low and CD26 hi compartments) migrate to skin to involve in inflammatory responses.
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Keywords of your Abstract : |
Psoriasis, Regulatory T cells, CD26 |
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Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/39244/Forms/762/abstract.pdf |
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The presentation : |
Poster |
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The Cover of Abstract book : |
http://gsia.tums.ac.ir/images/UserFiles/39244/Forms/762/cover_1.pdf |
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Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/39244/Forms/762/book page_2.pdf |
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Where has your abstract been indexed? : |
none |
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If you choose other, please name : |
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The Congress Reporting Form
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How many volunteers were present at the Congress? : |
more than 8000 attendees |
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Delegates from which countries presented in the congress? : |
Iran, UK, USA, Italy, Japan |
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Were the delegates of any other organizations present in the congress? : |
No |
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If yes, please write the names of the organizations in the box : |
NO |
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What were the responses to your talking points? Were specific questions or concerns raised? : |
Some questions were asked regarding my abstract, about the methods and results. There weren't specific questions. |
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If you met staff members, please list their full names & positions. : |
No |
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Please inform us if there are any follow up actions we need to talk with the members of the congress : |
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Your experiences about the travel processes(Providing ticket, accommodation,...) : |
In my mind, it would be great by providing better facilities, international department of University could support and help students for international congress attendance. I had problem to get an introduction letter for embassy. |
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Please give a briefing of your own observations and outcomes of the congress: : |
The European Academy of Allergy and Clinical Immunology (EAACI) is a well known organization. EAACI 2017 was very well organized. Each program was held on time. I had discussion with other students about their work. It was a very nice experience |