PARICHEHR PASBAKHSH | International Congress Form
Application Code :
762-0217-0061
Created Date : Tuesday, October 3, 2017-09:58 09:58:38Update Date : Tuesday, October 3, 2017-11:45 11:45:00
IP Address : 194.225.51.101Submit Date : Tuesday, October 3, 2017-11:46 11:46:40Email :PASBAKHS@SINA.TUMS.AC.IR
Personal Information
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Name : |
parichehr |
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Surname : |
PASBAKHSH |
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School/Research center : |
School of Medicine |
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If you choose other, please name your Research center : |
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Position : |
Professor |
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Tel : |
+98-21-44644585 |
Information of Congress
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Title of the Congress : |
MIPTEC BASEL LIFE |
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Title of your Abstract : |
Enhancement of homing in transplanted bone marrow derived mesenchymal stem cells under pretreatment with melatonin in a rat model of liver fibrosis |
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Destination Country : |
Switzerland |
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From : |
Sunday, September 10, 2017 |
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To : |
Wednesday, September 13, 2017 |
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Abstract(Please copy/paste the abstract send to the congress) : |
Enhances the Homing of Bone Marrow-derived Mesenchymal Stem Cells Following Transplantation in a Rat Model of Liver Fibrosis
Keywan Mortezaee,1 Parichehr Pasbakhsh,1 Iraj Ragerdi Kashani,1,* Fatemeh Sabbaghziarani,1 Ameneh Omidi,1 Adib Zendedel,2 Soudabeh Ghasemi,1 and Ahmad Reza Dehpour3
Author information ► Article notes ► Copyright and License information ►
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Abstract
Background:
Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has been considered as a promising milestone in liver fibrosis treatment. However, low amounts of homing are a major obstacle. We aimed to investigate the role of melatonin pretreatment in BMMSC homing into experimental liver fibrosis.
Methods:
BMMSCs were obtained, grown, propagated and preconditioned with 5 µM melatonin and analyzed for multipotency and immunophenotypic features at passage three. The cells were labelled with CM-Dil and infused into the rats received the i.p. injection of carbon tetrachloride (CCl4) for five weeks to induce liver fibrosis. Animals were divided into two groups: One group received BMMSCs, whereas the other group received melatonin-pretreated BMMSCs (MT-BMMSCs). After cell injection at 72 h, animals were sacrificed, and the liver tissues were assessed for further evaluations: fibrosis using Masson’s trichrome and hematoxylin and eosin staining and homing using fluorescent microscopy and flow cytometry.
Results:
BMMSCs and MT-BMMSCs expressed a high level of CD44 but low levels of CD11b, CD45 and CD34 (for all P≤0.05) and were able to differentiate into adipocytes and Schwann cells. CCl4 induction resulted in extensive collagen deposition, tissue disruption and fatty accumulation with no obvious difference between the two groups. There was a significant increase in homing of MT-BMMSCs in both florescent microscopy (P≤0.001) and flow cytometry (P≤0.01) assays, as compared with non-treated BMMSCs.
Conclusion:
This study indicates the improved homing potential of BMMSCs in pretreatment with melatonin. Therefore, this strategy may represent an applied approach for improving the stem cell therapy of liver fibrosis. |
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Keywords of your Abstract : |
Bone marrow, Mesenchymal stem cells, Melatonin |
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Acceptance Letter : |
http://gsia.tums.ac.ir/images/UserFiles/41073/Forms/762/request.pdf |
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The presentation : |
Poster |
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The Cover of Abstract book : |
 |
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Published abstract in the abstract book with the related code : |
http://gsia.tums.ac.ir/images/UserFiles/41073/Forms/762/Basel_LIFE_-_Innovation_Forums_-_Abstract_Submission_System1.pdf |
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Where has your abstract been indexed? : |
none |
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If you choose other, please name : |
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The Congress Reporting Form
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How many volunteers were present at the Congress? : |
more than 600 |
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Delegates from which countries presented in the congress? : |
Switzerland- United Kingdom- United States-Germany- Czech Republic-Finland-India-France-Tiwan-Moscow-CanadaDenmark...... |
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Were the delegates of any other organizations present in the congress? : |
No |
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If yes, please write the names of the organizations in the box : |
- |
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What were the responses to your talking points? Were specific questions or concerns raised? : |
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If you met staff members, please list their full names & positions. : |
Jennifer lippinco |
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Please inform us if there are any follow up actions we need to talk with the members of the congress : |
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Your experiences about the travel processes(Providing ticket, accommodation,...) : |
The fee set for this scientific trip by Tehran university of medical sciences does not correspond to actual travel costs, including the cost of booking tickets and hotels and the daily living costs of a foreign country |
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Please give a briefing of your own observations and outcomes of the congress: : |
Annually the Miptec event has been one of the largest gathering of the companies and associations working to serve the life science industry in Europe. The event has grown year after year and changed to reflect the dynamics of the evolving science research and development landscape . Bridging the worlds of science and business
Basel Life combines science, technology, and exhibition in a unique way to bridge not only between basic science and translational science but also between science and business.The role of the industry representatives on the steering committee is to help facilitate a successful exposition event for all the presenting companies and make the event productive and engaging for the many talented associates and scientists attending the conference.
2017 was the first year of EMBO at Basel Life, organised by the European Molecular Biology Organisation (EMBO) and chaired by Susan Gasser, Maria Leptin and a group of leading scientists. This high-ranking international scientific meeting was combined with the well-established industry exhibition MipTec and a range of Innovation Forums on technology, application and business.
The event attacts an international audience from over 45 countries.The goal is to foster interaction between the different players in the value chain of life science research.This year opportunities to interact rest on three pillars . EMBO at Basel life with a stellar program covering basic research.This event is in its first year in Basel and features preeminent researchers with the topic Genomes in biology and medicine.This year the poster exhibition is shared with the EMBO conference.
The conferece brings together outstanding researchers who will present work on all aspects of genome biology ,ranging from microbial genomes and genome evolution to transcription ,inheritance and clinical approaches |