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Code : 9345-353890 Created Date : Monday, January 15, 2018 Visit : 1774

The report of 13th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology by Dr. Ismaeil Haririan

Application Code :

762-0217-0076

Created Date : Sunday, October 22, 2017-11:34 11:34:14Update Date : Tuesday, December 5, 2017-14:07 14:07:36
IP Address : 194.225.58.20Submit Date : Tuesday, December 5, 2017-14:08 14:08:13Email : haririan@tums.ac.ir

Personal Information

Name :	Ismaeil
Surname :	Haririan
School/Research center :	School of Pharmacy
If you choose other, please name your Research center :
Position :	Professor
Tel :	+21-664-82607

Information of Congress

Title of the Congress :	13th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology
Title of your Abstract :	Curcumin-loaded nanoparticles used for breast cancer treatment
Destination Country :	Italy
From :	Monday, July 24, 2017
To :	Tuesday, July 25, 2017
Abstract(Please copy/paste the abstract send to the congress) :	Abstract To contrive against the obstacles in physicochemical properties of curcumin, various carriers and delivery systems have been introduced in the past two decades. Among a multitude of potential vehicles, the prospective effects of the liposomes and lipid-structures in improving the pharmacokinetic and dynamic of turmeric compounds have numerously been reported in recent studies. Besides, peptides that modulate cancer cell specific molecular pathways have a great potential as anticancer therapeutics. Among them, peptides that induce cell death via apoptosis have attracted ever-increasing attention. Tumor homing peptides and peptidomimetics containing RGD or NGR motifs have been exploited for targeting of therapeutics or diagnostics to cells with an overexpression of αυβ integrin family of adhesion receptors. On the other hands, studies have demonstrated that KLA peptides with a sequence of (KLAKLAK)2 can induce apoptosis in cancer cells. However, cell internalization is perceived as a major obstacle for development of such pharmaceutically useful peptides. Many efforts have been done to optimize ACP properties through two approaches: computational design and delivery systems. Among the carriers, gold nanoparticles offer a safe delivery platforms for anticancer agent development. Self-assembled structures were prepared from the oleyl-peptide at pH 3, 5.5, and 7. Curcumin was also dispersed in aqueous phase at neutral pH and was further separated from the colloidal particles and precipitates through filtration. According to the results, the more cytotoxicity and cellular uptake by T47D and MCF-7 breast cancer cells were observed for the smaller NPs in size an aspect ratio (AR) in which T47D cells was more sensitive than MCF-7 cells. The MTT results were confirmed by the morphological changes for the cancer cells exposed to NPs. Our finding suggested that the biological and pro-apoptotic effects of the mitochondrial targeting peptide were tuned by P-AuNPs upon their size and shape.
Keywords of your Abstract :	nanoparticles, KLA peptides, Curcumin, T47D and MCF-7 breast cancer cells
Acceptance Letter :	http://gsia.tums.ac.ir/images/UserFiles/29433/Forms/762/acceptance_letter_8.pdf
The presentation :	Oral
The Cover of Abstract book :	http://gsia.tums.ac.ir/images/UserFiles/29433/Forms/762/The_Cover_of_Abstract_book_1.pdf
Published abstract in the abstract book with the related code :	http://gsia.tums.ac.ir/images/UserFiles/29433/Forms/762/صفحه_مربوط_به_Published_abstract__1.pdf
Where has your abstract been indexed? :	Scoups
If you choose other, please name :

The Congress Reporting Form

How many volunteers were present at the Congress? :	30
Delegates from which countries presented in the congress? :	Austaria, USA, Russia, UK, France, switzerland, Japan, Greece, India, Portugal, Italy, Iran,
Were the delegates of any other organizations present in the congress? :	Yes
If yes, please write the names of the organizations in the box :	Kyle M. Jandrasitz Senior Applications Engineer Microfluidics Inc. Westwood, MA, USA +1 (781) 708-0312 kjandrasitz@idexcorp.com
What were the responses to your talking points? Were specific questions or concerns raised? :	good
If you met staff members, please list their full names & positions. :	1) Istvan Toth; Professor Drug delivery in the University of Queensland, Australia; h.toth@uq.edu.au 2) Martina V.Zueva; Professor of Pathophysiology in Helmhotlz Moscow research Institute of Eye disease, Russia visionlab@yandex.ru 3) Christine Charrueau; Professor of Pharmaceutics in Universite Paris Descartes, France, christine.charrueau@parisdescartes.fr
Please inform us if there are any follow up actions we need to talk with the members of the congress :	they invite me for the next years' conference.
Your experiences about the travel processes(Providing ticket, accommodation,...) :	I got the ticket from the Iran Air.
Please give a briefing of your own observations and outcomes of the congress: :	The academic outcomes of the conference were medium, so I'll look the highest conference for my next attendance.

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