Tehran University of Medical Sciences
Office of Vice-Chancellor for Global Strategies & International Affairs
International Human Capacity Development (IHCD)
Code : 9822-353263      Publish Date : Monday, August 7, 2017 Visit : 2974

Intl. Congress form | International Congress Report | International Congress Report For Students and Staff | International Student Congress of (bio)Medical Sciences (ISCOMS) by Khashayar Afshari

International Student Congress of (bio)Medical Sciences (ISCOMS) by Khashayar Afshari
International Student Congress of (bio)Medical Sciences (ISCOMS) by Khashayar Afshari
Application Code :
762-0117-0024
 
Created Date : Wednesday, June 28, 2017-19:57 19:57:20Update Date : Friday, June 30, 2017-17:07 17:07:57
IP Address : 93.114.24.139Submit Date : Friday, June 30, 2017-17:06 17:06:40Email : Khashayarafshari@gmail.com
Personal Information
Name : Khashayar
Surname : Afshari
School/Research center : School of Medicine
If you choose other, please name your Research center :  
Position : student
Tel : +98-21-22868867
Information of Congress
Title of the Congress : International Student Congress of (bio)Medical Sciences (ISCOMS)
Title of your Abstract : Protective effect of Metformin against spinal cord injury in male rats
Destination Country : Netherlands
From : Tuesday, June 6, 2017
To : Friday, June 9, 2017
Abstract(Please copy/paste the abstract send to the congress) : Introduction: Spinal Cord Injury (SCI) is a disabling disease that happens due to damage spinal cord resulting in loss of cord’s motor, sensory and autonomic functions. Studies have shown that Metformin is an inhibitor of mammalian Target Of Rapamycin (mTOR) and this inhibition leads to attenuation of neuronal damage and locomotor impairment in spinal cord injury. Our objective is to investigate the effect of metformin on repair of rat SCI through inhibition of mTOR. Material & methods: A total of forty-five male rats (weight 250-300g) were used in this study. Experiments were performed to determine a dose of metformin that effectively improves locomotor and sensory scores in rats with SCI. Therefore, rats received different doses of Metformin (10, 50,100 mg/kg intraperitoneal) or saline 1 hour before surgery. SCI was induced by compressing the T9 spinal segment with an aneurysmal clip for 60 seconds in anesthetized rats. After the surgery during four weeks of study Tail flick latency (TFL) and BBB (Basso-Beattie-Bresnahan) locomotor score were evaluated. Locomotor scores were determined at 1, 3,5,7,14,21 and 28 days after SCI. Spinal histopathologies were examined 30 days after SCI. Results:our preliminary results showed an overall significant improvement in locomotor scores of rats with SCI was observed Within-Subjects repeated measures (P =0.004,) is observed. In the Between-Subjects analysis, medium dose metformin monotherapy (metformin 50 mg/kg) had a superior impact compared to low- and high-dose metformin (10 mg/kg and 50 mg/kg, respectively) and control saline on increasing locomotor scores at different intervals post SCI. Conclusion: Studies have shown inhibition of mTOR reduces neuronal damage and locomotor impairment after spinal cord injury also producing neuroprotective effects and reducing secondary damage at the lesion. Although the effects of Metformin, a known inhibitor of mTOR which is also a safe known drug for diabetes, has never been studied in spinal cord injury. In this study we evaluated the therapeutic effects of metformin in SCI of rats. Results shows a presumably mTor inhibition induced improvement of locomotion through histopatholigicaly demonstrated neuroprotection and damage reduction. Metformin also showed to have protective effects against neuropathic pain which is a sensory complication of SCI
Keywords of your Abstract : Metformin,Spinal Cord injury,rats
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/38791/Forms/762/Letter_of_acceptance_2017_-_Khashayar_Afshari_1_.pdf
The presentation : Poster
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/38791/Forms/762/book_of_abstracts_.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/38791/Forms/762/book of abstracts _1.pdf
Where has your abstract been indexed? : other
If you choose other, please name : my poster will be published in F1000Research which is an Open Research publishing platform offering immediate publication of articles and other research outputs with no editorial bias. All articles benefit from transparent peer review and the inclusion of all source data.
The Congress Reporting Form
How many volunteers were present at the Congress? : 600
Delegates from which countries presented in the congress? : Italy, Afghanistan, Argentina, Australia, Austria, Belarus, Belgium, Brazil, Brunei , Bulgaria, Chile,China, Denmark, France, India, Indonesia, Iran, Mexico, Netherlands, Netherlands Antilles, New Zealand, Norway, Poland, Portugal, Russia and ...
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : EMSA,IFMSA,European Students’ Conference,AMSA,AIMS,
What were the responses to your talking points? Were specific questions or concerns raised? : I had my poster presented for a group of professors and students regarding my topic and i got advises on adding on groups to my research for it's improvement and also i was asked about the initiation of the idea for my research and it's development.it was very helpful and i got many brilliant ideas from their points and also other presentations which i am sure will help me a lot with my future research.
If you met staff members, please list their full names & positions. : Prof. Marian Joels PhD Dean/member of the board of directors University Medical Center Groningen
Prof Ruud M.M Bos DMD phD 
Prof. Paul de Vos PhD
Please inform us if there are any follow up actions we need to talk with the members of the congress : it would be great if the Tehran university of medical Sciences could contact the congress for better coordination so there will be less problems for the procedures of visa and introducing the congress to the university
Your experiences about the travel processes(Providing ticket, accommodation,...) : at the time that my article was accepted for the congress Tehran university of Medical Sciences had not started giving the travel grant to the students for medical congresses before the event and also the process of getting the permission for going to another country was very very hard and time taking specifically for males who have military service and have to bale two separate times for the military and university to travel.it would be great if the university could ease and shorten these processes and make the bales less expensive.
Please give a briefing of your own observations and outcomes of the congress: : As a medical student at Tehran University of Medical Sciences (TUMS) I have begun my researches with Prof. Ahmad Reza Dehpour as my supervisor in TUMS pharmacology department and Brain and Spinal Injury Research Center since 2013. 
I know the integration of research, and clinical knowledge is the key in solving clinical problems. As I am seriously considering continue my researches in the fields of basic science and clinic after I qualify as an M.D. I am keenly interested in acquiring more theoretical knowledge and practical skills in these areas. As a medical student and a researcher in TUMS, I have gained laboratory experience and co-authored some basic science articles especially pharmacology with Professor Dehpour, my academic objective is to develop in the field of basic sciences with a special focus on the applying new findings in solving clinical problems such as use of drugs in spinal cord injury and memory impairment for treatment and palliation which I have worked on lately.
After I found out about this congress, I found it very influential in my academic future. For sure this opportunity brought me a great experience in an international environment and a networking opportunity with students and professors from all over the world.
Also as one of my latest research abstracts have been accepted to be presented in this congress i was really eager to be able to present my work in this occasion. It was very fortunate that I could have participated in this experience 
I had my poster presented for a group of professors and students regarding my topic and i got advises on adding on groups to my research for its improvement and also i was asked about the initiation of the idea for my research and it's development.it was very helpful and i got many brilliant ideas from their points and also other presentations which i am sure will help me a lot with my future research.