Code : 9345-339919      Created Date : Sunday, August 10, 2014   Update Date : Sunday, August 10, 2014    Visit : 2005

ASBMT Tandem Meetings 2014

The report of ASBMT Tandem Meetings 2014 by Dr. Amir Ali Hamidieh

 

Application Code :
306-0114-0053
 
Created Date : Sunday, June 08, 2014 09:09:04Update Date : Thursday, July 03, 2014 10:02:06IP Address :194.225.48.9
Submit Date : Thursday, July 03, 2014 10:02:21Email : aahamidieh@sina.tums.ac.ir
Personal Information
Name : Amir Ali
Surname : Hamidieh
School/Research center : Hematology-Oncology and Stem Cell Transplantation Research Center (HORCSCT)
If you choose other, please name your Research center :  
Possition : Associate professor
Tel : +98-21-88004140
E-mail : aahamidieh@tums.ac.ir
Information of Congress
Title of the Congress : ASBMT Tandem Meetings 2014
Title of your Abstract : Encouraging Leukemia free survival rates in 72 pediatric acute lymphoblastic leukemia (ALL) in CR undergoing allogeneic hematopoietic stem cell transplantation using a TBI free conditioning regimen
country : USA
From : Wednesday, February 26, 2014
To : Sunday, March 02, 2014
Abstract(Please copy/paste the abstract send to the congress) : Background: TBI-based preparative regimen has been widely recommended for pediatric ALL. These assumptions are based on older registry studies. Because of the significantly high rates of serious late effect using TBI in pediatric patients it is of utmost importance to find alternative regimens. Chemotherapy regimens are developed to minimize the toxicities of irradiation-based regimens.

Methods: Since the year 1994, 111 pediatric patients (78 male&33female: 72 in CR and 39 not in CR) with ALL underwent HSCT in our center using a TBI-free conditioning. Here, we describe the outcomes of HSCT of the 72 patients in CR: 30 patients were in first CR, 28 second CR, and 14 ≥third CR. Only very high-risk patients underwent HSCT in the first CR. Patients were treated and classified according to BFM protocols. The conditioning regimen was included of Busulfan (IV or Oral) and Cyclophosphamide with or without ATG. For GVHD prophylaxis, patients received cyclosporine with or without methotrexate.

Outcomes: Patients underwent transplantation from sibling donors (n=58), other related donors (n=10), unrelated donor (n=4). Source of grafts were peripheral blood (n=60), bone marrow (n=7) and cord blood (n=5). The probability of neutrophil engraftment (at day60) was 94+-3% (med.time to of 14days) and of platelets-engraftment was 90+-10% (med.time 22days). The estimated 5-year leukemic free survival (LFS) was 73%+-6% (82+-7% in CR1, 71+-10% in CR2 and 38+-25% in CR>=2). Relapse rates were 8+-5% in CR1, 22+-9% in CR2 and 20+-17% in CR>=2. Acute GvHD grade 2-4 occurred in 49+-5% patients and 15+-5% patients have experienced chronic extended GvHD.

Conclusion: A TBI-free (Bu/Cy) preparative regimens can be used in pediatric ALL with encouraging LFS rates, similar to what is reported in literature using TBI. Well-designed randomized trials are needed to better clarify the difference between radiation and TBI-free conditioning regimens in pediatric ALL, including late effects.
Disclosures:
Nothing To Disclose
Keywords of your Abstract : ALL, hematopoietic stem cell transplantation , TBI.free
Acceptance Letter :
The presentation : Oral
The Cover of Abstract book :
Published abstract in the abstract book with the related code :
Where has your abstract been indexed? : Pubmed
If you choose other, please name :  
   
   
   
   
The Congress Reporting Form
How many volunteers were present at the Congress? : more than 3000
Delegates from which countries presented in the congress? : more than 40 countries, USA, Germany, Japan, Netherland, Austria
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : EBMT, APBMT, EMBMT
What were the responses to your talking points? Were specific questions or concerns raised? : yes, mostly about the relapse rate and transplant related mortality.they were very interested about the usage of TBI free, also there were some question about the kind of ATG and Busulfan that we used.the number of pediatric stem cell transplantation in our center was unbeliveble for many of particpate and they asked about our rate disease transplantation.
If you met staff members, please list their full names & positions. : E.J.Shpall President of ASBMT
A.Madrigal President of EBMT
Y.Kodera President of APBMT
Please inform us if there are any follow up actions we need to talk with the members of the congress : yes,Tehran university of Medical Sciences can invite many speakers about HSCT to Iran and also we can start collaboration between our university and other universities.I had a very useful and good meeting with chairman of pediatric working party of EBMT(Prof.Peters) and also with head of pediatric stem cell transplantation.
Your experiences about the travel processes(Providing ticket, accommodation,...) : travel was very expensive
Please give a briefing of your own observations and outcomes of the congress: : very well organized .up date topics about mesanchymal stem cell and cell therapy new and model methods. there were a lot of abstract about the use of minimal residul disease (MRD) after HSCT in pediatric patient with acute leukemia and how a transplant physical has to trat a patient with relapse of leukemia after transplantation.very well organized .up date topics about mesanchymal stem cell and cell therapy new and model methods. there were a lot of abstract about the use of minimal residul disease (MRD) after HSCT in pediatric patient with acute leukemia and how a transplant physical has to.

 

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