Code : 9345-346844      Created Date : Tuesday, May 19, 2015   Update Date : Tuesday, May 19, 2015    Visit : 1526

Pharmacology-Nutrition 2015

The report of Pharmacology-Nutrition 2015 by Dr. Azam Bakhtiarian
 
Application Code :
306-0115-0061
 
Created Date : Saturday, May 9, 2015 11:18:11Update Date : Sunday, May 17, 2015 11:54:20
IP Address : 194.225.51.101Submit Date : Sunday, May 17, 2015 11:54:39Email : bakhtiar@tums.ac.ir
Personal Information
Name : Azam
Surname : Bakhtiarian
School/Research center : School of Medicine
If you choose other, please name your Research center :  
Position : Associate professor
Tel : +98-21-66402569
Information of Congress
Title of the Congress : Pharmacology-Nutrition 2015
Title of your Abstract : Prostaglandin F2α modulates atrial chronotropic hyporesponsiveness to cholinergic stimulation in endotoxemic rats
country : USA
From : Monday, April 13, 2015
To : Wednesday, April 15, 2015
Abstract(Please copy/paste the abstract send to the congress) : Prostaglandin F2α modulates atrial chronotropic hyporesponsiveness to cholinergic stimulation in endotoxemic rats
A. Bakhtiarian, V. Nikoui, S. Ejtemaei-Mehr, S. Ostadhadi, G. Eftekhari, A.R. Dehpour, F. Jazaeri, A.R. Mani

There is evidence to show that endotoxemia-induced inflammatory tachycardia might be linked to a direct action of prostanoids on the cardiac pacemaker cells. Recent reports have indicated that systemic inflammation may uncouple of cardiac pacemaker from cholinergic neural control in experimental animals, however, the exact mechanism of this phenomenon is uncertain. This study was aimed to explore the hypothesis that prostanoids modulate atrial chronotropic hyporesponsiveness to cholinergic stimulation in endotoxemic rats.
Male albino rats were given intraperitoneal injection of either saline or lipopolysaccharide (LPS, 1 mg/kg). Three hours after saline or LPS injection, the atria were isolated and chronotropic responsiveness to cholinergic stimulation was evaluated in presence of indomethacin (COX inhibitor) and antagonists and analogues of prostaglandin F2α (PGF2α) and thromboxane A2 (TXA2) in an organ bath. The expression of atrial cyclooxygenases (COX)-1, COX-2 and COX-3 and PGF2α receptor (FP) and TXA2 receptor (TP) mRNA was assessed by quantitative real-time RT-PCR and cytosolic calcium-dependent phospholipase A2 (cPLA2) activity was measured in the atria.
The expression of atrial COX-2 mRNA and cPLA2 activity increased significantly in endotoxemic atria (P<0.05). Incubation with PGF2α (100 pM) could significantly decrease chronotropic response to cholinergic stimulation in vitro. Likewise, LPS injection could induce a significant hyporesponsiveness to cholinergic stimulation, and incubation of isolated atria with either indomethacin (5 μM) or AL-8810 (a PGF2α antagonist, 10 μM) could reverse it (P<0.01, P<0.05, respectively), while SQ29548 (a thromboxane A2 antagonist, 10 nM) was failed (P>0.05).
Our data showed that PGF2α may contribute to the atrial chronotropic hyporesponsiveness to cholinergic stimulation in endotoxemic rats.
Keywords of your Abstract : Prostaglandin F2α , atria, hyporesponsiveness, endotoxemic , rats
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/24703/Forms/306/Poster_Acceptance_LetterPGF2_AA.pdf
The presentation : Poster
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/24703/Forms/306/Doc2_Book_cover.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/24703/Forms/306/viewsecurePDF_PGF2.pdf
Where has your abstract been indexed? : Pubmed
If you choose other, please name :  
The Congress Reporting Form
How many volunteers were present at the Congress? : 200
Delegates from which countries presented in the congress? : Usa, Canada, Iran, Australia, Africa, India, Egypt, Sweden
Were the delegates of any other organizations present in the congress? : No
If yes, please write the names of the organizations in the box :  
What were the responses to your talking points? Were specific questions or concerns raised? : I presented evidence showing that endotoxemia-induced inflammatory tachycardia might be linked to a direct action of prostanoids on the cardiac pacemaker cells due to the fact that systemic inflammation may uncouple of cardiac pacemaker from cholinergic neural control in experimental animals. However, we studied the role of prostanoids in this modulation of atrial chronotropic hyporesponsiveness to cholinergic stimulation in endotoxemic rats. They asked if we studied the role of different serotonergic receptors in our project.
If you met staff members, please list their full names & positions. : Dr. Ali Keshavarsian, Rush Univ. Medical center,
Dr. Khashayarsha Khazaie, Mayo Clinic, College of Medicine and Graduate School, Usa
Please inform us if there are any follow up actions we need to talk with the members of the congress : No follow up actions required. As a matter of fact it was a good apportunity for me as a cardiovascular pharmacology graduate that had nutrition background to attend a congress focused on disease specific topic including immunology, metabolic and neurological disorders, micrbiome management and food pharma interactions.
Your experiences about the travel processes(Providing ticket, accommodation,...) : Getting visa was the most time consuming process.
Please give a briefing of your own observations and outcomes of the congress: : This congress focused on aspects of molecular characteristics of food ingredients towards clinical effectiveness and relevance. This meeting represents an innovative scientific platform totally dedicated to unique and challenging interface between nutrition and pharmacology. The meeting focused on disease specific topic including immunology, metabolic and neurological disorders, micrbiome management and food pharma interactions. The presentation by Dr. Marette showed that omega-3 fatty acids are potent suppressors of inflammation and protects from type2 diabetes through novel glucoregulatory mechanism, and thus may be used in combination with statins to reduce cardiovascular outcomes in obese dyslipidemic subjects. The growing evidence that the gut microbiota is a key determinant of diet-induced obesity and type2 diabetes was discussed. he showed evidence that new polyphenol-rich extracts from cranberry and other wild berries can protect against obesity and type2 diabetes and non-alcohol fatty-liver disease.in high fat-fed mice.

 

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