Code : 9345-352488      Created Date : Saturday, March 4, 2017   Visit : 1465

The report of The Ninth Annual Conference of International Association of Neurorestoratology (IANR) by Dr. Somayeh Ebrahimi Barough

The report of The Ninth Annual Conference of International Association of Neurorestoratology (IANR) by Dr. Somayeh Ebrahimi Barough
Application Code :
306-0216-0102
 
Created Date : Monday, June 20, 2016-14:55 14:55:29Update Date : Saturday, January 21, 2017-12:30 12:30:01
IP Address : 192.168.58.213Submit Date : Saturday, January 21, 2017-12:30 12:30:10Email :ebrahimi_s@sina.tums.ac.ir
Personal Information
Name : soamyeh
Surname : ebrahimi-barough
School/Research center : School of Advanced Technology in Medicine
If you choose other, please name your Research center :  
Position : Assistant professor
Tel : +98-21-43052000
Information of Congress
Title of the Congress : The Ninth Annual Conference of International Association of Neurorestoratology (IANR)
Title of your Abstract : LY294002 small molecule promote motor neuron differentiation of human endometrial stem cells cultured on electrospun biocomposite Polycaprolactone/Collagen scaffolds
Destination Country : China (People's Republic of China)
From : Wednesday, August 31, 2016
To : Sunday, September 4, 2016
Abstract(Please copy/paste the abstract send to the congress) : Small molecules as useful chemical tools can affect cell differentiation and even change cell fate. It is demonstrated that LY294002, a small molecule inhibitor of PI3K/Akt signal pathway, can inhibit proliferation and promote neuronal differentiation of mesenchymal stem cells (MSCs). The purpose of this study was to investigate the differentiation effect of Ly294002 small molecule on the human endometrial stem cells (hEnSCs) into motor neuron like cells on polycaprolactone (PCL)/Collagen scaffolds. hEnSCs were cultured in a neurogenic inductive medium contain 1µM LY294002 on the surface of PCL/Collagen electrospun fibrous scaffolds. Cell attachment and viability of cells on scaffolds were characterized by SEM and MTT assay. The expression of neuron-specific markers was assayed by real-time PCR and immunocytochemistry analysis after 15days post induction. Results showed that attachment and differentiation of hEnSCs into motor neuron-like cells on the scaffolds with Ly294002 small molecule were higher than that of the cells on tissue culture plates as control group. In conclusion, PCL/ collagen electrospun scaffolds with Ly294002 have potential for being used in neural tissue engineering because of its bioactive and three-dimensional structure which enhances viability and differentiation of hEnSCs into neurons through inhibition of the PI3K/Akt pathway that manipulation of this pathway by small molecules can enhance neural differentiation.
Keywords of your Abstract : PI3K/Akt signaling, small molecule, differentiation, motor neuron cells, PCL/Collagen scaffold
Acceptance Letter : http://gsia.tums.ac.ir/images/UserFiles/30973/Forms/306/invitation.pdf
The presentation : Oral
The Cover of Abstract book : http://gsia.tums.ac.ir/images/UserFiles/30973/Forms/306/45.pdf
Published abstract in the abstract book with the related code : http://gsia.tums.ac.ir/images/UserFiles/30973/Forms/306/chap.pdf
Where has your abstract been indexed? : none
If you choose other, please name :  
The Congress Reporting Form
How many volunteers were present at the Congress? : 150
Delegates from which countries presented in the congress? : china,india,USA,Iran, Argentina, Japan, Taiwan, hong kong, Russia, Australia, Italy, south korea, UK
Were the delegates of any other organizations present in the congress? : Yes
If yes, please write the names of the organizations in the box : China, Japan, UK
What were the responses to your talking points? Were specific questions or concerns raised? : My present was interesting for audience because of using tissue engineering and stem cells for spinal cord injury treatment.
If you met staff members, please list their full names & positions. : dr.nandini gokulchandran(India), prof.gustavo A.Moviglia (argantina), Alok sharma(india), wise young (USA), Russel J Andrews(USA),Ping Wu(USA)
Please inform us if there are any follow up actions we need to talk with the members of the congress : prof.gustavo A.Moviglia (argantina) director of centre for tissue, engineering and cellular therapy research, Argentina. He is chairman in the next IANR congress in Argentina. His email is 
movinglia.gustavo@maimonides.edu Dr Hoshangh Saberi is other professor in Iran that attended in this congress as a chairman. His email is saberih@tums.ac.ir
you can talk about cell therapy for spinal cord injured people and treatment of them.
Your experiences about the travel processes(Providing ticket, accommodation,...) : all process were done by passenger agency and our groups. we attended in this congress with 6 people from TUMS and tehran university, our viza were group viza for 7days.
Please give a briefing of your own observations and outcomes of the congress: : My study is based on neural tissue engineering, in this congress, many surgeons attended and I obtained new insight about spinal cord injury treatment specifically in human. They used stem cells from different sources and injected in spinal cord injured site. The results were interesting and patients after cell transplantation could walk. I talk about the big problem in the cell therapy that is low survival of cells in the region of injury and for solving this problem I talk about tissue engineering and application of scaffold for cell seeding on them. It was interesting for them specially surgeons.

 

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